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Association between insulin resistance and the development of cardiovascular disease

Overview of attention for article published in Cardiovascular Diabetology, August 2018
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#11 of 877)
  • High Attention Score compared to outputs of the same age (95th percentile)

Mentioned by

twitter
83 tweeters
facebook
1 Facebook page
reddit
1 Redditor
q&a
1 Q&A thread
video
2 video uploaders

Citations

dimensions_citation
94 Dimensions

Readers on

mendeley
338 Mendeley
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Title
Association between insulin resistance and the development of cardiovascular disease
Published in
Cardiovascular Diabetology, August 2018
DOI 10.1186/s12933-018-0762-4
Pubmed ID
Authors

Valeska Ormazabal, Soumyalekshmi Nair, Omar Elfeky, Claudio Aguayo, Carlos Salomon, Felipe A. Zuñiga

Abstract

For many years, cardiovascular disease (CVD) has been the leading cause of death around the world. Often associated with CVD are comorbidities such as obesity, abnormal lipid profiles and insulin resistance. Insulin is a key hormone that functions as a regulator of cellular metabolism in many tissues in the human body. Insulin resistance is defined as a decrease in tissue response to insulin stimulation thus insulin resistance is characterized by defects in uptake and oxidation of glucose, a decrease in glycogen synthesis, and, to a lesser extent, the ability to suppress lipid oxidation. Literature widely suggests that free fatty acids are the predominant substrate used in the adult myocardium for ATP production, however, the cardiac metabolic network is highly flexible and can use other substrates, such as glucose, lactate or amino acids. During insulin resistance, several metabolic alterations induce the development of cardiovascular disease. For instance, insulin resistance can induce an imbalance in glucose metabolism that generates chronic hyperglycemia, which in turn triggers oxidative stress and causes an inflammatory response that leads to cell damage. Insulin resistance can also alter systemic lipid metabolism which then leads to the development of dyslipidemia and the well-known lipid triad: (1) high levels of plasma triglycerides, (2) low levels of high-density lipoprotein, and (3) the appearance of small dense low-density lipoproteins. This triad, along with endothelial dysfunction, which can also be induced by aberrant insulin signaling, contribute to atherosclerotic plaque formation. Regarding the systemic consequences associated with insulin resistance and the metabolic cardiac alterations, it can be concluded that insulin resistance in the myocardium generates damage by at least three different mechanisms: (1) signal transduction alteration, (2) impaired regulation of substrate metabolism, and (3) altered delivery of substrates to the myocardium. The aim of this review is to discuss the mechanisms associated with insulin resistance and the development of CVD. New therapies focused on decreasing insulin resistance may contribute to a decrease in both CVD and atherosclerotic plaque generation.

Twitter Demographics

The data shown below were collected from the profiles of 83 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 338 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 338 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 59 17%
Student > Master 46 14%
Student > Ph. D. Student 44 13%
Researcher 35 10%
Student > Postgraduate 24 7%
Other 64 19%
Unknown 66 20%
Readers by discipline Count As %
Medicine and Dentistry 79 23%
Biochemistry, Genetics and Molecular Biology 66 20%
Nursing and Health Professions 31 9%
Agricultural and Biological Sciences 22 7%
Pharmacology, Toxicology and Pharmaceutical Science 17 5%
Other 36 11%
Unknown 87 26%

Attention Score in Context

This research output has an Altmetric Attention Score of 53. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 May 2020.
All research outputs
#402,760
of 15,354,298 outputs
Outputs from Cardiovascular Diabetology
#11
of 877 outputs
Outputs of similar age
#13,382
of 275,492 outputs
Outputs of similar age from Cardiovascular Diabetology
#1
of 1 outputs
Altmetric has tracked 15,354,298 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 877 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.2. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 275,492 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them