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Reprogramming barriers and enhancers: strategies to enhance the efficiency and kinetics of induced pluripotency

Overview of attention for article published in Cell Regeneration, January 2015
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (84th percentile)

Mentioned by

blogs
1 blog
twitter
2 tweeters
facebook
1 Facebook page

Citations

dimensions_citation
53 Dimensions

Readers on

mendeley
135 Mendeley
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Title
Reprogramming barriers and enhancers: strategies to enhance the efficiency and kinetics of induced pluripotency
Published in
Cell Regeneration, January 2015
DOI 10.1186/s13619-015-0024-9
Pubmed ID
Authors

Behnam Ebrahimi

Abstract

Induced pluripotent stem cells are powerful tools for disease modeling, drug screening, and cell transplantation therapies. These cells can be generated directly from somatic cells by ectopic expression of defined factors through a reprogramming process. However, pluripotent reprogramming is an inefficient process because of various defined and unidentified barriers. Recent studies dissecting the molecular mechanisms of reprogramming have methodically improved the quality, ease, and efficiency of reprogramming. Different strategies have been applied for enhancing reprogramming efficiency, including depletion/inhibition of barriers (p53, p21, p57, p16(Ink4a)/p19(Arf), Mbd3, etc.), overexpression of enhancing genes (e.g., FOXH1, C/EBP alpha, UTF1, and GLIS1), and administration of certain cytokines and small molecules. The current review provides an in-depth overview of the cutting-edge findings regarding distinct barriers of reprogramming to pluripotency and strategies to enhance reprogramming efficiency. By incorporating the mechanistic insights from these recent findings, a combined method of inhibition of roadblocks and application of enhancing factors may yield the most reliable and effective approach in pluripotent reprogramming.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 135 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 <1%
Spain 1 <1%
France 1 <1%
Unknown 132 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 39 29%
Researcher 21 16%
Student > Bachelor 20 15%
Student > Master 17 13%
Student > Postgraduate 8 6%
Other 14 10%
Unknown 16 12%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 48 36%
Agricultural and Biological Sciences 35 26%
Medicine and Dentistry 11 8%
Chemistry 7 5%
Neuroscience 4 3%
Other 8 6%
Unknown 22 16%

Attention Score in Context

This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 January 2016.
All research outputs
#1,692,082
of 14,011,199 outputs
Outputs from Cell Regeneration
#6
of 50 outputs
Outputs of similar age
#42,936
of 282,271 outputs
Outputs of similar age from Cell Regeneration
#1
of 1 outputs
Altmetric has tracked 14,011,199 research outputs across all sources so far. Compared to these this one has done well and is in the 87th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 50 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.4. This one scored the same or higher as 44 of them.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 282,271 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 84% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them