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Epigenomics of mammary gland development

Overview of attention for article published in Breast Cancer Research, September 2018
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (85th percentile)
  • Good Attention Score compared to outputs of the same age and source (76th percentile)

Mentioned by

news
1 news outlet
twitter
9 X users
facebook
1 Facebook page

Citations

dimensions_citation
31 Dimensions

Readers on

mendeley
104 Mendeley
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Title
Epigenomics of mammary gland development
Published in
Breast Cancer Research, September 2018
DOI 10.1186/s13058-018-1031-x
Pubmed ID
Authors

Holly Holliday, Laura A. Baker, Simon R. Junankar, Susan J. Clark, Alexander Swarbrick

Abstract

Differentiation of stem cells into highly specialised cells requires gene expression changes brought about by remodelling of the chromatin architecture. During this lineage-commitment process, the majority of DNA needs to be packaged into inactive heterochromatin, allowing only a subset of regulatory elements to remain open and functionally required genes to be expressed. Epigenetic mechanisms such as DNA methylation, post-translational modifications to histone tails, and nucleosome positioning all potentially contribute to the changes in higher order chromatin structure during differentiation. The mammary gland is a particularly useful model to study these complex epigenetic processes since the majority of its development is postnatal, the gland is easily accessible, and development occurs in a highly reproducible manner. Inappropriate epigenetic remodelling can also drive tumourigenesis; thus, insights into epigenetic remodelling during mammary gland development advance our understanding of breast cancer aetiology. We review the current literature surrounding DNA methylation and histone modifications in the developing mammary gland and its implications for breast cancer.

X Demographics

X Demographics

The data shown below were collected from the profiles of 9 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 104 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 104 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 19 18%
Student > Ph. D. Student 18 17%
Student > Bachelor 11 11%
Researcher 11 11%
Student > Doctoral Student 6 6%
Other 8 8%
Unknown 31 30%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 33 32%
Agricultural and Biological Sciences 14 13%
Medicine and Dentistry 5 5%
Pharmacology, Toxicology and Pharmaceutical Science 3 3%
Computer Science 3 3%
Other 10 10%
Unknown 36 35%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 15. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 May 2019.
All research outputs
#2,471,128
of 25,385,509 outputs
Outputs from Breast Cancer Research
#237
of 2,054 outputs
Outputs of similar age
#49,275
of 345,580 outputs
Outputs of similar age from Breast Cancer Research
#8
of 34 outputs
Altmetric has tracked 25,385,509 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,054 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.2. This one has done well, scoring higher than 88% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 345,580 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 85% of its contemporaries.
We're also able to compare this research output to 34 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 76% of its contemporaries.