↓ Skip to main content

Transcatheter arterial chemoembolization combined with CT‐guided percutaneous thermal ablation versus hepatectomy in the treatment of hepatocellular carcinoma

Overview of attention for article published in Cancer Communications, June 2015
Altmetric Badge

Mentioned by

twitter
3 X users

Citations

dimensions_citation
30 Dimensions

Readers on

mendeley
20 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Transcatheter arterial chemoembolization combined with CT‐guided percutaneous thermal ablation versus hepatectomy in the treatment of hepatocellular carcinoma
Published in
Cancer Communications, June 2015
DOI 10.1186/s40880-015-0023-9
Pubmed ID
Authors

Sheng Li, Liang Zhang, Zhi-Mei Huang, Pei-Hong Wu

Abstract

Transcatheter arterial chemoembolization (TACE) plus thermal ablation has been widely used recently in the treatment of hepatocellular carcinoma (HCC). In this study, we aimed to compare results of the combination of TACE and percutaneous thermal ablation with those of hepatectomy in patients with HCC. The clinical data of 137 HCC patients who sequentially received TACE and computed tomography (CT)-guided percutaneous thermal ablation as an initial curative treatment (combination group) and 148 matched HCC patients who received hepatectomy (surgery group) between 2004 and 2011 were collected and analyzed. After TACE, multiphase contrast-enhanced CT was performed to identify the total number of tumors as well as lipiodol deposition in the liver. Survival was calculated by using the Kaplan-Meier method and compared by using the log-rank test. The prognostic factors were assessed with multivariate Cox proportional hazards regression analysis. Of all 285 patients, 225 (79.0 %) had cancerous lesions ≤ 5 cm in diameter. In preoperative contrast-enhanced CT or magnetic resonance imaging, the number of tumors was 1-4 for each patient. The 1-, 3-, and 5-year overall survival rates were 95, 74 %, and 67 % in the combination group and 88, 66, and 47 % in the surgery group, respectively (P = 0.004); the corresponding recurrence-free survival rates for the two groups were 92, 69, and 61 % and 75, 58, and 44 %, respectively (P = 0.001). In the multivariate analysis, treatment allocation was an independent prognostic factor for survival. Only 60 patients in the combination group had sufficient imaging data, and 135 new lesions with lipiodol deposition were diagnosed as malignancies in 22 of 60 patients, whereas 20 new lesions were found in 11 of 148 patients in the surgery group. The combination of TACE and CT-guided percutaneous thermal ablation for HCC improves survival of HCC patients compared with hepatectomy.

X Demographics

X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 20 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 20 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 4 20%
Lecturer 2 10%
Student > Bachelor 2 10%
Student > Ph. D. Student 2 10%
Professor 1 5%
Other 4 20%
Unknown 5 25%
Readers by discipline Count As %
Medicine and Dentistry 7 35%
Nursing and Health Professions 4 20%
Biochemistry, Genetics and Molecular Biology 2 10%
Computer Science 1 5%
Arts and Humanities 1 5%
Other 0 0%
Unknown 5 25%