Chapter title |
Fluctuations of Nutrition-Associated Markers After Decompressive Hemicraniectomy in Middle Cerebral Artery Occlusion Patients
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Chapter number | 6 |
Book title |
Oxygen Transport to Tissue XL
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Published in |
Advances in experimental medicine and biology, August 2018
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DOI | 10.1007/978-3-319-91287-5_6 |
Pubmed ID | |
Book ISBNs |
978-3-31-991285-1, 978-3-31-991287-5
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Authors |
Nobuo Kutsuna, Kotaro Makita, Kosei Goto, Koki Hirayama, Goro Kido, Yukihide Kagawa, Kutsuna, Nobuo, Makita, Kotaro, Goto, Kosei, Hirayama, Koki, Kido, Goro, Kagawa, Yukihide |
Abstract |
Cerebral infarction (CI) caused by middle cerebral artery occlusion exhibits a very high mortality rate. To reduce this rate, a decompressive hemicraniectomy (DHC) is performed clinically based on several randomized trials. In ischemic stroke, a state of malnutrition leads to poor outcomes. However, little evidence is available on nutrition state in the acute phase after DHC. This preliminary study focuses on serum markers, especially dynamic or static nutrition-associated markers including prealbumin, transferrin, retinol binding protein (RBP) and serum albumin under tube feeding with Peptamen®AF (Nestlé Health Science Japan). Blood samples were collected from four patients and analyzed at 6 time points over 14 days (preoperative day, post-operative day (POD) 1, POD 3, POD 7, POD 10, and POD 14). One-way analysis of variance (ANOVA), post hoc Least Significant Difference (LSD), was employed to analyze the blood levels at each time point. The prealbumin and RBP levels showed no significant difference between preoperation and POD 3, although they decreased gradually, while transferrin decreased significantly between the preoperative day and POD 3 (P < 0.05). The level increased significantly on POD 14 as compared to POD 3 (P < 0.05) for each dynamic marker, respectively. The albumin value decreased significantly on POD 3 to POD 7 as compared to the preoperational day (P < 0.05), while the total protein fell significantly on POD 3 (P < 0.05). The total cholesterol, HDL cholesterol, LDL cholesterol, triglyceride, glucose, transferrin, and C-reactive protein were also investigated. Some markers fluctuated significantly, especially on POD 3. The duration may represent a hypercatabolic phase for malignant cerebral infarction with DHC. Based on these findings, further investigations among these markers, the tube fed contents, physiological changes and disability could lead to better outcomes following malignant CI. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 18 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 5 | 28% |
Unspecified | 2 | 11% |
Student > Master | 2 | 11% |
Student > Ph. D. Student | 1 | 6% |
Other | 1 | 6% |
Other | 2 | 11% |
Unknown | 5 | 28% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 3 | 17% |
Unspecified | 2 | 11% |
Biochemistry, Genetics and Molecular Biology | 2 | 11% |
Neuroscience | 2 | 11% |
Psychology | 2 | 11% |
Other | 1 | 6% |
Unknown | 6 | 33% |