Chapter title |
Monitoring of Brain Oxygenation During and After Cardiopulmonary Resuscitation: A Prospective Porcine Study
|
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Chapter number | 14 |
Book title |
Oxygen Transport to Tissue XL
|
Published in |
Advances in experimental medicine and biology, August 2018
|
DOI | 10.1007/978-3-319-91287-5_14 |
Pubmed ID | |
Book ISBNs |
978-3-31-991285-1, 978-3-31-991287-5
|
Authors |
Yasuyuki Kakihana, Chinatsu Kamikokuryo, Hiroaki Furubeppu, Yutaro Madokoro, Takahiro Futatsuki, Shotaro Miyamoto, Hiroyuki Haraura, Kousaku Hatanaka, Tomohiro Eguchi, Yasuo Saitoh, Naoki Miura, Hiroaki Suzuki, Yukio Ueda, Tomotsugu Yasuda, Takashi Ito, Kakihana, Yasuyuki, Kamikokuryo, Chinatsu, Furubeppu, Hiroaki, Madokoro, Yutaro, Futatsuki, Takahiro, Miyamoto, Shotaro, Haraura, Hiroyuki, Hatanaka, Kousaku, Eguchi, Tomohiro, Saitoh, Yasuo, Miura, Naoki, Suzuki, Hiroaki, Ueda, Yukio, Yasuda, Tomotsugu, Ito, Takashi |
Abstract |
This study aimed to evaluate the usefulness of near-infrared time-resolved spectroscopy (TRS) for the monitoring of post-resuscitation encephalopathy. Cardiac arrest (CA) was induced in pigs by electrical stimuli; then, return of spontaneous circulation (ROSC) was achieved by direct current. The changes in cerebral oxygenation were analyzed by two methods: (1) the time-independent calculation based on the modified Beer-Lambert law (MBL), and (2) the curve-fitting method based on the photon diffusion theory (DT). The changes in reduced scattering coefficient (μs') in DT were also calculated. Post-resuscitation encephalopathy was evaluated by MRI findings. During CA, cerebral oxygen saturation (ScO2) decreased to the lowest level, and then gradually increased during the chest compression period. When ROSC was achieved, ScO2 (DT) increased further, but ScO2 (MBL) decreased transiently. This strange phenomenon disappeared when the scalp was peeled off and the probes were directly fixed to the cranial bone. In some cases, a sustained decrease in μs' was observed several hours after ROSC and, in such cases, MRI Diffusion Enhancement Image (DWI) showed findings suggestive of post-resuscitation encephalopathy. In conclusion, simultaneous monitoring of cerebral oxygenation with MBL and DT may provide more information about the vascular response of different layers. Also, the monitoring of μs' may help us to recognize the occurrence of post-resuscitation encephalopathy in real time. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 15 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Professor | 2 | 13% |
Student > Bachelor | 2 | 13% |
Unspecified | 1 | 7% |
Other | 1 | 7% |
Student > Doctoral Student | 1 | 7% |
Other | 2 | 13% |
Unknown | 6 | 40% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 5 | 33% |
Unspecified | 1 | 7% |
Materials Science | 1 | 7% |
Earth and Planetary Sciences | 1 | 7% |
Unknown | 7 | 47% |