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Mendeley readers
Attention Score in Context
| Title |
Epigenetic alterations following early postnatal stress: a review on novel aetiological mechanisms of common psychiatric disorders
|
|---|---|
| Published in |
Clinical Epigenetics, November 2015
|
| DOI | 10.1186/s13148-015-0156-3 |
| Pubmed ID | |
| Authors |
Magdalene C. Jawahar, Chris Murgatroyd, Emma L. Harrison, Bernhard T. Baune |
| Abstract |
Stressor exposure during early life has the potential to increase an individual's susceptibility to a number of neuropsychiatric conditions such as mood and anxiety disorders and schizophrenia in adulthood. This occurs in part due to the dysfunctional stress axis that persists following early adversity impairing stress responsivity across life. The mechanisms underlying the prolonged nature of this vulnerability remain to be established. Alterations in the epigenetic signature of genes involved in stress responsivity may represent one of the neurobiological mechanisms. The overall aim of this review is to provide current evidence demonstrating changes in the epigenetic signature of candidate gene(s) in response to early environmental adversity. More specifically, this review analyses the epigenetic signatures of postnatal adversity such as childhood abuse or maltreatment and later-life psychopathology in human and animal models of early life stress. The results of this review shows that focus to date has been on genes involved in the regulation of hypothalamic-pituitary-adrenal (HPA) axis and its correlation to subsequent neurobiology, for example, the role of glucocorticoid receptor gene. However, epigenetic changes in other candidate genes such as brain-derived neurotrophic factor (BDNF) and serotonin transporter are also implicated in early life stress (ELS) and susceptibility to adult psychiatric disorders. DNA methylation is the predominantly studied epigenetic mark followed by histone modifications specifically acetylation and methylation. Further, these epigenetic changes are cell/tissue-specific in regulating expression of genes, providing potential biomarkers for understanding the trajectory of early stress-induced susceptibility to adult psychiatric disorders. |
X Demographics
The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 20% |
| South Africa | 1 | 20% |
| United States | 1 | 20% |
| France | 1 | 20% |
| Unknown | 1 | 20% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 80% |
| Scientists | 1 | 20% |
Mendeley readers
The data shown below were compiled from readership statistics for 236 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Mexico | 2 | <1% |
| Germany | 1 | <1% |
| Turkey | 1 | <1% |
| Switzerland | 1 | <1% |
| Canada | 1 | <1% |
| Netherlands | 1 | <1% |
| Unknown | 229 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 44 | 19% |
| Student > Master | 33 | 14% |
| Researcher | 30 | 13% |
| Student > Bachelor | 23 | 10% |
| Student > Doctoral Student | 15 | 6% |
| Other | 42 | 18% |
| Unknown | 49 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 41 | 17% |
| Medicine and Dentistry | 34 | 14% |
| Psychology | 30 | 13% |
| Agricultural and Biological Sciences | 26 | 11% |
| Biochemistry, Genetics and Molecular Biology | 21 | 9% |
| Other | 23 | 10% |
| Unknown | 61 | 26% |
Attention Score in Context
This research output has an Altmetric Attention Score of 82. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 February 2024.
All research outputs
#529,402
of 26,017,215 outputs
Outputs from Clinical Epigenetics
#17
of 1,458 outputs
Outputs of similar age
#7,598
of 295,474 outputs
Outputs of similar age from Clinical Epigenetics
#2
of 27 outputs
Altmetric has tracked 26,017,215 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,458 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.6. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 295,474 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 27 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 92% of its contemporaries.