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A potential mode of action for Anakinra in patients with arthrofibrosis following total knee arthroplasty

Overview of attention for article published in Scientific Reports, November 2015
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  • Above-average Attention Score compared to outputs of the same age (51st percentile)
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Mentioned by

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2 tweeters

Citations

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17 Dimensions

Readers on

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31 Mendeley
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Title
A potential mode of action for Anakinra in patients with arthrofibrosis following total knee arthroplasty
Published in
Scientific Reports, November 2015
DOI 10.1038/srep16466
Pubmed ID
Authors

David Dixon, Jonathon Coates, Alicia del Carpio Pons, Joanna Horabin, Andrew Walker, Nicole Abdul, Nicholas S. Kalson, Nigel T. Brewster, David J. Weir, David J. Deehan, Derek A. Mann, Lee A. Borthwick

Abstract

Arthrofibrosis is a fibroproliferative disease characterised by excessive deposition of extracellular matrix components intra-articularly leading to pain and restricted range of movement. Although frequently observed following total knee arthroplasty (TKA) no therapeutic options exist. A pilot study demonstrated that intra-articular injection of Anakinra, an IL-1R antagonist, improved range of movement and pain in patients with arthrofibrosis however the mechanism of action is unknown. We hypothesise that IL-1α/β will drive an inflammatory phenotype in fibroblasts isolated from the knee, therefore identifying a potential mechanism of action for Anakinra in arthrofibrosis following TKA. Fibroblasts isolated from synovial membranes and infra-patellar fat pad of patients undergoing TKA express high levels of IL-1R1. Stimulation with IL-1α/β induced a pro-inflammatory phenotype characterised by increased secretion of GMCSF, IL-6 and IL-8. No significant difference in the inflammatory response was observed between fibroblasts isolated from synovial membrane or infra-patellar fat pad. IL-1α/β treatments induced a pro-inflammatory phenotype in fibroblasts from both synovial membrane and infra-patellar fat pad and therefore Anakinra can likely have an inhibitory effect on fibroblasts present in both tissues in vivo. It is also likely that fibroblast responses in the tissues are controlled by IL-1α/β availability and not their ability to respond to it.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 31 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 31 100%

Demographic breakdown

Readers by professional status Count As %
Student > Postgraduate 4 13%
Student > Doctoral Student 4 13%
Student > Ph. D. Student 3 10%
Other 3 10%
Student > Bachelor 3 10%
Other 9 29%
Unknown 5 16%
Readers by discipline Count As %
Medicine and Dentistry 15 48%
Biochemistry, Genetics and Molecular Biology 2 6%
Agricultural and Biological Sciences 2 6%
Immunology and Microbiology 1 3%
Social Sciences 1 3%
Other 3 10%
Unknown 7 23%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 November 2015.
All research outputs
#9,348,507
of 15,925,797 outputs
Outputs from Scientific Reports
#42,772
of 83,064 outputs
Outputs of similar age
#168,671
of 367,893 outputs
Outputs of similar age from Scientific Reports
#1,768
of 3,533 outputs
Altmetric has tracked 15,925,797 research outputs across all sources so far. This one is in the 39th percentile – i.e., 39% of other outputs scored the same or lower than it.
So far Altmetric has tracked 83,064 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 16.2. This one is in the 45th percentile – i.e., 45% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 367,893 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 51% of its contemporaries.
We're also able to compare this research output to 3,533 others from the same source and published within six weeks on either side of this one. This one is in the 46th percentile – i.e., 46% of its contemporaries scored the same or lower than it.