↓ Skip to main content

Targeting Mitochondrial Function to Treat Quiescent Tumor Cells in Solid Tumors.

Overview of attention for article published in International Journal of Molecular Sciences, November 2015
Altmetric Badge

About this Attention Score

  • Average Attention Score compared to outputs of the same age
  • Average Attention Score compared to outputs of the same age and source

Mentioned by

twitter
2 tweeters

Readers on

mendeley
39 Mendeley
Title
Targeting Mitochondrial Function to Treat Quiescent Tumor Cells in Solid Tumors.
Published in
International Journal of Molecular Sciences, November 2015
DOI 10.3390/ijms161126020
Pubmed ID
Authors

Zhang, Xiaonan, de Milito, Angelo, Olofsson, Maria Hägg, Gullbo, Joachim, D'Arcy, Padraig, Linder, Stig, Xiaonan Zhang, Angelo de Milito, Maria Hägg Olofsson, Joachim Gullbo, Padraig D’Arcy, Stig Linder

Abstract

The disorganized nature of tumor vasculature results in the generation of microenvironments characterized by nutrient starvation, hypoxia and accumulation of acidic metabolites. Tumor cell populations in such areas are often slowly proliferating and thus refractory to chemotherapeutical drugs that are dependent on an active cell cycle. There is an urgent need for alternative therapeutic interventions that circumvent growth dependency. The screening of drug libraries using multicellular tumor spheroids (MCTS) or glucose-starved tumor cells has led to the identification of several compounds with promising therapeutic potential and that display activity on quiescent tumor cells. Interestingly, a common theme of these drug screens is the recurrent identification of agents that affect mitochondrial function. Such data suggest that, contrary to the classical Warburg view, tumor cells in nutritionally-compromised microenvironments are dependent on mitochondrial function for energy metabolism and survival. These findings suggest that mitochondria may represent an "Achilles heel" for the survival of slowly-proliferating tumor cells and suggest strategies for the development of therapy to target these cell populations.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 39 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 3%
Unknown 38 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 15 38%
Researcher 7 18%
Student > Master 6 15%
Student > Doctoral Student 3 8%
Other 2 5%
Other 6 15%
Readers by discipline Count As %
Agricultural and Biological Sciences 11 28%
Biochemistry, Genetics and Molecular Biology 10 26%
Medicine and Dentistry 6 15%
Pharmacology, Toxicology and Pharmaceutical Science 2 5%
Unspecified 2 5%
Other 8 21%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 May 2017.
All research outputs
#6,294,292
of 8,674,965 outputs
Outputs from International Journal of Molecular Sciences
#2,918
of 5,732 outputs
Outputs of similar age
#185,274
of 299,646 outputs
Outputs of similar age from International Journal of Molecular Sciences
#145
of 309 outputs
Altmetric has tracked 8,674,965 research outputs across all sources so far. This one is in the 23rd percentile – i.e., 23% of other outputs scored the same or lower than it.
So far Altmetric has tracked 5,732 research outputs from this source. They receive a mean Attention Score of 2.5. This one is in the 40th percentile – i.e., 40% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 299,646 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 32nd percentile – i.e., 32% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 309 others from the same source and published within six weeks on either side of this one. This one is in the 46th percentile – i.e., 46% of its contemporaries scored the same or lower than it.