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Quercetin protects the retina by reducing apoptosis due to ischemia-reperfusion injury in a rat model

Overview of attention for article published in Arquivos Brasileiros de Oftalmologia, January 2015
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#16 of 166)
  • Good Attention Score compared to outputs of the same age (77th percentile)
  • High Attention Score compared to outputs of the same age and source (83rd percentile)

Mentioned by

blogs
1 blog

Citations

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27 Dimensions

Readers on

mendeley
28 Mendeley
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Title
Quercetin protects the retina by reducing apoptosis due to ischemia-reperfusion injury in a rat model
Published in
Arquivos Brasileiros de Oftalmologia, January 2015
DOI 10.5935/0004-2749.20150026
Pubmed ID
Authors

Sedat Arikan, Ismail Ersan, Turan Karaca, Selcuk Kara, Baran Gencer, Ihsan Karaboga, Hasan Ali Tufan

Abstract

This study aimed to investigate the effect of quercetin on apoptotic cell death induced by ischemia-reperfusion (I/R) injury in the rat retina. Twenty-four rats were divided into four equal groups: control, ischemic, solvent, and quercetin. I/R injury was achieved by elevating the intraocular pressure above the perfusion pressure. Intraperitoneal injections of 20 mg/kg of quercetin and dimethyl sulfoxide (DMSO) were performed in the quercetin and solvent groups, respectively, immediately prior to I/R injury, and the researchers allowed for the retinas to be reperfused. Forty-eight hours after injury, the thicknesses of the retinal ganglion cell layer (RGCL), inner nuclear layer (INL), inner plexiform layer (IPL), outer plexiform layer (OPL), and outer nuclear layer (ONL) were measured in all groups. Moreover, the numbers of terminal deoxynucleotidyl transferase dUTP nick-end-labeled [TUNEL (+)] cells and caspase-3 (+) cells in both INL and ONL were evaluated in all groups. The administration of quercetin was found to reduce the thinning of all retinal layers. The mean thickness of INL in the quercetin and ischemic groups was 21 ± 5.6 µm and 16 ± 6.4 µm, respectively (P<0.05). Similarly, the mean thickness of ONL in the quercetin and ischemic groups was 50 ± 12.8 µm and 40 ± 8.7 µm, respectively (P<0.05). The antiapoptotic effect of quercetin in terms of reducing the numbers of both TUNEL (+) cells and caspase-3 (+) cells was significant in INL. The mean number of TUNEL (+) cells in INL in the ischemic and quercetin groups was 476.8 ± 45.6/mm2 and 238.72 ± 251/mm2, respectively (P<0.005). The mean number of caspase-3 (+) cells in INL of ischemic and quercetin groups was 633.6 ± 38.7/mm2 and 342.4 ± 36.1/mm2, respectively (P<0.001). The use of quercetin may be beneficial in the treatment of retinal I/R injury because of its antiapoptotic effect on the retinal layers, particularly in INL.

Mendeley readers

The data shown below were compiled from readership statistics for 28 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Turkey 1 4%
Unknown 27 96%

Demographic breakdown

Readers by professional status Count As %
Researcher 5 18%
Student > Master 5 18%
Student > Postgraduate 3 11%
Student > Bachelor 2 7%
Other 2 7%
Other 4 14%
Unknown 7 25%
Readers by discipline Count As %
Medicine and Dentistry 5 18%
Agricultural and Biological Sciences 5 18%
Biochemistry, Genetics and Molecular Biology 2 7%
Neuroscience 2 7%
Veterinary Science and Veterinary Medicine 1 4%
Other 3 11%
Unknown 10 36%

Attention Score in Context

This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 November 2015.
All research outputs
#2,905,478
of 12,471,795 outputs
Outputs from Arquivos Brasileiros de Oftalmologia
#16
of 166 outputs
Outputs of similar age
#75,459
of 339,214 outputs
Outputs of similar age from Arquivos Brasileiros de Oftalmologia
#5
of 30 outputs
Altmetric has tracked 12,471,795 research outputs across all sources so far. Compared to these this one has done well and is in the 76th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 166 research outputs from this source. They receive a mean Attention Score of 1.8. This one has done particularly well, scoring higher than 91% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 339,214 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 77% of its contemporaries.
We're also able to compare this research output to 30 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 83% of its contemporaries.