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Atomistic Study of Zwitterionic Peptoid Antifouling Brushes

Overview of attention for article published in Langmuir, August 2018
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  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (80th percentile)
  • High Attention Score compared to outputs of the same age and source (95th percentile)

Mentioned by

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1 blog
twitter
3 tweeters

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22 Mendeley
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Title
Atomistic Study of Zwitterionic Peptoid Antifouling Brushes
Published in
Langmuir, August 2018
DOI 10.1021/acs.langmuir.8b01939
Pubmed ID
Authors

David L. Cheung, King Hang Aaron Lau

Abstract

Using molecular dynamics (MD) simulations, we study the molecular behavior and hydration properties of a set of zwitterionic "peptoid" brushes, grafted on a rutile surface, that has been previously reported to exhibit excellent resistance against protein adsorption and cell attachment. Peptoids are novel poly( N-substituted glycine) peptide mimics with the side chains attached to amide nitrogens. They constitute a unique model polymer system because hundreds of side chains have been demonstrated, and the exact chain length and sequence order of the residues/monomers may be specified in experiments. In this report, we vary the brush grafting density as well as the side chain/polymer molecular volume. We include in our study polysarcosine as an uncharged comparison with a small polymer chain cross-section. Sarcosine is the simplest peptoid residue with only a nominally hydrophobic methyl group as side chain, but is also reported to exhibit high antifouling performance. Overall, we show in detail how molecular volume and hydration effects are intertwined in a zwitterionic polymer brush. For example, the zwitterionic design significantly promotes extended chain conformations and could actually lower the overall electrostatic potential. Some properties promoted by the balanced charges, such as chain flexibility and hydration, increase more prominently at "low" to "intermediate" chain densities. These and other observations should provide insight on the molecular behavior of peptoids and inform the design of zwitterionic antifouling polymer brushes.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 22 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 22 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 6 27%
Student > Ph. D. Student 5 23%
Student > Bachelor 3 14%
Student > Master 2 9%
Other 2 9%
Other 3 14%
Unknown 1 5%
Readers by discipline Count As %
Chemistry 7 32%
Chemical Engineering 3 14%
Materials Science 3 14%
Physics and Astronomy 2 9%
Economics, Econometrics and Finance 1 5%
Other 4 18%
Unknown 2 9%

Attention Score in Context

This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 September 2018.
All research outputs
#1,644,840
of 13,543,688 outputs
Outputs from Langmuir
#223
of 10,241 outputs
Outputs of similar age
#51,869
of 263,770 outputs
Outputs of similar age from Langmuir
#8
of 181 outputs
Altmetric has tracked 13,543,688 research outputs across all sources so far. Compared to these this one has done well and is in the 87th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 10,241 research outputs from this source. They receive a mean Attention Score of 3.4. This one has done particularly well, scoring higher than 97% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 263,770 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 80% of its contemporaries.
We're also able to compare this research output to 181 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 95% of its contemporaries.