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High-fat Diet Promotes Cardiac Remodeling in an Experimental Model of Obesity

Overview of attention for article published in Arquivos Brasileiros de Cardiologia, August 2015
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Title
High-fat Diet Promotes Cardiac Remodeling in an Experimental Model of Obesity
Published in
Arquivos Brasileiros de Cardiologia, August 2015
DOI 10.5935/abc.20150095
Pubmed ID
Authors

Fernando Martins, Dijon Henrique Salomé Campos, Luana Urbano Pagan, Paula Felippe Martinez, Katashi Okoshi, Marina Politi Okoshi, Carlos Roberto Padovani, Albert Schiaveto de Souza, Antonio Carlos Cicogna, Silvio Assis de Oliveira-Junior

Abstract

Although nutritional, metabolic and cardiovascular abnormalities are commonly seen in experimental studies of obesity, it is uncertain whether these effects result from the treatment or from body adiposity. To evaluate the influence of treatment and body composition on metabolic and cardiovascular aspects in rats receiving high saturated fat diet. Sixteen Wistar rats were used, distributed into two groups, the control (C) group, treated with isocaloric diet (2.93 kcal/g) and an obese (OB) group, treated with high-fat diet (3.64 kcal/g). The study period was 20 weeks. Analyses of nutritional behavior, body composition, glycemia, cholesterolemia, lipemia, systolic arterial pressure, echocardiography, and cardiac histology were performed. High-fat diet associates with manifestations of obesity, accompanied by changes in glycemia, cardiomyocyte hypertrophy, and myocardial interstitial fibrosis. After adjusting for adiposity, the metabolic effects were normalized, whereas differences in morphometric changes between groups were maintained. It was concluded that adiposity body composition has a stronger association with metabolic disturbances in obese rodents, whereas the high-fat dietary intervention is found to be more related to cardiac morphological changes in experimental models of diet-induced obesity.

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The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 31 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 31 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 4 13%
Student > Master 3 10%
Lecturer 2 6%
Student > Bachelor 1 3%
Professor > Associate Professor 1 3%
Other 0 0%
Unknown 20 65%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 3 10%
Agricultural and Biological Sciences 3 10%
Pharmacology, Toxicology and Pharmaceutical Science 1 3%
Nursing and Health Professions 1 3%
Sports and Recreations 1 3%
Other 2 6%
Unknown 20 65%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 November 2015.
All research outputs
#15,517,312
of 25,373,627 outputs
Outputs from Arquivos Brasileiros de Cardiologia
#371
of 1,210 outputs
Outputs of similar age
#140,185
of 277,639 outputs
Outputs of similar age from Arquivos Brasileiros de Cardiologia
#1
of 17 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,210 research outputs from this source. They receive a mean Attention Score of 4.0. This one has gotten more attention than average, scoring higher than 68% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 277,639 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 48th percentile – i.e., 48% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 17 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 94% of its contemporaries.