Title |
Challenges and Strategies in Thermal Processing of Amorphous Solid Dispersions: A Review
|
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Published in |
AAPS PharmSciTech, August 2015
|
DOI | 10.1208/s12249-015-0393-y |
Pubmed ID | |
Authors |
Justin S. LaFountaine, James W. McGinity, Robert O. Williams |
Abstract |
Thermal processing of amorphous solid dispersions continues to gain interest in the pharmaceutical industry, as evident by several recently approved commercial products. Still, a number of pharmaceutical polymer carriers exhibit thermal or viscoelastic limitations in thermal processing, especially at smaller scales. Additionally, active pharmaceutical ingredients with high melting points and/or that are thermally labile present their own specific challenges. This review will outline a number of formulation and process-driven strategies to enable thermal processing of challenging compositions. These include the use of traditional plasticizers and surfactants, temporary plasticizers utilizing sub- or supercritical carbon dioxide, designer polymers tailored for hot-melt extrusion processing, and KinetiSol® Dispersing technology. Recent case studies of each strategy will be described along with potential benefits and limitations. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 33% |
Unknown | 2 | 67% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 3 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | <1% |
Ireland | 1 | <1% |
Unknown | 156 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 31 | 20% |
Student > Master | 24 | 15% |
Researcher | 17 | 11% |
Other | 11 | 7% |
Student > Bachelor | 8 | 5% |
Other | 22 | 14% |
Unknown | 45 | 28% |
Readers by discipline | Count | As % |
---|---|---|
Pharmacology, Toxicology and Pharmaceutical Science | 59 | 37% |
Chemistry | 7 | 4% |
Biochemistry, Genetics and Molecular Biology | 5 | 3% |
Engineering | 5 | 3% |
Materials Science | 5 | 3% |
Other | 20 | 13% |
Unknown | 57 | 36% |