Title |
Neurological features of 14q24-q32 interstitial deletion: report of a new case
|
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Published in |
Molecular Cytogenetics, November 2015
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DOI | 10.1186/s13039-015-0196-6 |
Pubmed ID | |
Authors |
Francesco Nicita, Marilena Di Giacomo, Orazio Palumbo, Emanuela Ferri, Daniela Maiorani, Federico Vigevano, Massimo Carella, Alessandro Capuano |
Abstract |
Interstitial deletions of the long arm of chromosome 14 involving the 14q24-q32 region have been reported in less than 20 patients. Previous studies mainly attempted to delineate recognizable facial dysmorphisms; conversely, descriptions on neurological features are limited to the presence of cognitive and motor delay, but no better characterization exists. In this paper we report on a patient with a de novo interstitial deletion of 5.5 Mb at 14q24.3-q31.1. The deletion encompasses 84 genes, including fourteen Mendelian genes. He presented with dysmorphic face, developmental delay, paroxysmal non-epileptic events and, subsequently, epilepsy. The clinical and molecular evaluation of this patient and the review of the literature expand the phenotype of 14q23-q32 deletion syndrome to include paroxysmal non-epileptic events and infantile-onset focal seizures. |
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United States | 1 | 100% |
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Members of the public | 1 | 100% |
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Unknown | 17 | 100% |
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Student > Bachelor | 3 | 18% |
Researcher | 2 | 12% |
Student > Postgraduate | 2 | 12% |
Student > Master | 2 | 12% |
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Other | 3 | 18% |
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Computer Science | 1 | 6% |
Other | 0 | 0% |
Unknown | 5 | 29% |