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Sex-specific differences in hepatic steatosis in obese spontaneously hypertensive (SHROB) rats

Overview of attention for article published in Biology of Sex Differences, September 2018
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Title
Sex-specific differences in hepatic steatosis in obese spontaneously hypertensive (SHROB) rats
Published in
Biology of Sex Differences, September 2018
DOI 10.1186/s13293-018-0202-x
Pubmed ID
Authors

Qingming Dong, Michael S. Kuefner, Xiong Deng, Dave Bridges, Edwards A. Park, Marshall B. Elam, Rajendra Raghow

Abstract

Patients with metabolic syndrome, who are characterized by co-existence of insulin resistance, hypertension, hyperlipidemia, and obesity, are also prone to develop non-alcoholic fatty liver disease (NAFLD). Although the prevalence and severity of NAFLD is significantly greater in men than women, the mechanisms by which gender modulates the pathogenesis of hepatic steatosis are poorly defined. The obese spontaneously hypertensive (SHROB) rats represent an attractive model of metabolic syndrome without overt type 2 diabetes. Although pathological manifestation caused by the absence of a functional leptin receptor has been extensively studied in SHROB rats, it is unknown whether these animals elicited sex-specific differences in the development of hepatic steatosis. We compared hepatic pathology in male and female SHROB rats. Additionally, we examined key biochemical and molecular parameters of signaling pathways linked with hyperinsulinemia and hyperlipidemia. Finally, using methods of quantitative polymerase chain reaction (qPCR) and western blot analysis, we quantified expression of 45 genes related to lipid biosynthesis and metabolism in the livers of male and female SHROB rats. We show that all SHROB rats developed hepatic steatosis that was accompanied by enhanced expression of SREBP1, SREBP2, ACC1, and FASN proteins. The livers of male rats also elicited higher induction of Pparg, Ppara, Slc2a4, Atox1, Skp1, Angptl3, and Pnpla3 mRNAs. In contrast, the livers of female SHROB rats elicited constitutively higher levels of phosphorylated JNK and AMPK and enhanced expression of Cd36. Based on these data, we conclude that the severity of hepatic steatosis in male and female SHROB rats was mainly driven by increased de novo lipogenesis. Moreover, male and female SHROB rats also elicited differential severity of hepatic steatosis that was coupled with sex-specific differences in fatty acid transport and esterification.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 38 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 38 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 6 16%
Student > Master 4 11%
Student > Bachelor 3 8%
Student > Ph. D. Student 3 8%
Lecturer 2 5%
Other 5 13%
Unknown 15 39%
Readers by discipline Count As %
Agricultural and Biological Sciences 5 13%
Biochemistry, Genetics and Molecular Biology 4 11%
Medicine and Dentistry 4 11%
Nursing and Health Professions 1 3%
Unspecified 1 3%
Other 2 5%
Unknown 21 55%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 September 2018.
All research outputs
#14,889,806
of 23,103,436 outputs
Outputs from Biology of Sex Differences
#348
of 476 outputs
Outputs of similar age
#199,176
of 337,287 outputs
Outputs of similar age from Biology of Sex Differences
#11
of 13 outputs
Altmetric has tracked 23,103,436 research outputs across all sources so far. This one is in the 34th percentile – i.e., 34% of other outputs scored the same or lower than it.
So far Altmetric has tracked 476 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 20.0. This one is in the 25th percentile – i.e., 25% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 337,287 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 40th percentile – i.e., 40% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 13 others from the same source and published within six weeks on either side of this one. This one is in the 15th percentile – i.e., 15% of its contemporaries scored the same or lower than it.