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Sodium butyrate improves antioxidant stability in sub-acute ruminal acidosis in dairy goats

Overview of attention for article published in BMC Veterinary Research, September 2018
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Title
Sodium butyrate improves antioxidant stability in sub-acute ruminal acidosis in dairy goats
Published in
BMC Veterinary Research, September 2018
DOI 10.1186/s12917-018-1591-0
Pubmed ID
Authors

Nana Ma, Juma Ahamed Abaker, Muhammad Shahid Bilal, Hongyu Dai, Xiangzhen Shen

Abstract

Currently, little is known about the effect of sodium butyrate (NaB) on oxidative stress following grain-induced sub-acute ruminal acidosis in dairy goats. In the present study, 18 lactating dairy goats implanted with a ruminal cannula and permanent indwelling catheters in the portal and hepatic veins were randomly allocated into 3 treatment groups over 20 weeks: low grain (LG, 40% grain; n = 6), high grain (HG, 60% grain; n = 6) and high grain with sodium butyrate (HG + NaB, 60% grain + NaB; n = 6). When added to the HG diet, NaB increased the mean ruminal pH and reduced the levels of ruminal, portal and hepatic LPS; Additionally, we observed an increase in SOD1, SOD2, SOD3, GPX1 and CAT mRNA expression, increased levels of TSOD and CAT enzyme activity as well as increased total antioxidant capacity (T-AOC) and decreased malondialdehyde (MDA) in both the liver and plasma, while GPx activity increased in the liver of goats fed the HG + NaB diet. The mRNA expression of UGT1A1, NQO1, MGST3, and Nrf2, as well as total Nrf2 protein levels were increased in goats fed the HG + NaB diet. Our study indicates that sodium butyrate could improve the oxidative status in sub-acute ruminal acidosis through the partial activation of Nrf2-dependent genes.

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The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 37 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 37 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 7 19%
Student > Doctoral Student 4 11%
Lecturer 2 5%
Student > Ph. D. Student 2 5%
Researcher 2 5%
Other 6 16%
Unknown 14 38%
Readers by discipline Count As %
Agricultural and Biological Sciences 10 27%
Veterinary Science and Veterinary Medicine 6 16%
Nursing and Health Professions 2 5%
Biochemistry, Genetics and Molecular Biology 1 3%
Social Sciences 1 3%
Other 1 3%
Unknown 16 43%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 November 2018.
All research outputs
#15,545,423
of 23,103,436 outputs
Outputs from BMC Veterinary Research
#1,440
of 3,084 outputs
Outputs of similar age
#213,164
of 337,287 outputs
Outputs of similar age from BMC Veterinary Research
#35
of 75 outputs
Altmetric has tracked 23,103,436 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,084 research outputs from this source. They receive a mean Attention Score of 3.9. This one is in the 44th percentile – i.e., 44% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 337,287 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 28th percentile – i.e., 28% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 75 others from the same source and published within six weeks on either side of this one. This one is in the 42nd percentile – i.e., 42% of its contemporaries scored the same or lower than it.