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Rapid functional genetics of the oligodendrocyte lineage using pluripotent stem cells

Overview of attention for article published in Nature Communications, September 2018
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (96th percentile)
  • High Attention Score compared to outputs of the same age and source (83rd percentile)

Mentioned by

news
7 news outlets
blogs
3 blogs
twitter
33 X users
facebook
1 Facebook page

Citations

dimensions_citation
21 Dimensions

Readers on

mendeley
78 Mendeley
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Title
Rapid functional genetics of the oligodendrocyte lineage using pluripotent stem cells
Published in
Nature Communications, September 2018
DOI 10.1038/s41467-018-06102-7
Pubmed ID
Authors

Angela M. Lager, Olivia G. Corradin, Jared M. Cregg, Matthew S. Elitt, H. Elizabeth Shick, Benjamin L. L. Clayton, Kevin C. Allan, Hannah E. Olsen, Mayur Madhavan, Paul J. Tesar

Abstract

Oligodendrocyte dysfunction underlies many neurological disorders, but rapid assessment of mutation-specific effects in these cells has been impractical. To enable functional genetics in oligodendrocytes, here we report a highly efficient method for generating oligodendrocytes and their progenitors from mouse embryonic and induced pluripotent stem cells, independent of mouse strain or mutational status. We demonstrate that this approach, when combined with genome engineering, provides a powerful platform for the expeditious study of genotype-phenotype relationships in oligodendrocytes.

X Demographics

X Demographics

The data shown below were collected from the profiles of 33 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 78 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 78 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 18 23%
Student > Ph. D. Student 13 17%
Other 6 8%
Student > Master 6 8%
Student > Doctoral Student 5 6%
Other 12 15%
Unknown 18 23%
Readers by discipline Count As %
Neuroscience 24 31%
Biochemistry, Genetics and Molecular Biology 18 23%
Agricultural and Biological Sciences 6 8%
Engineering 3 4%
Chemistry 2 3%
Other 6 8%
Unknown 19 24%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 84. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 September 2020.
All research outputs
#506,950
of 25,387,480 outputs
Outputs from Nature Communications
#8,613
of 56,487 outputs
Outputs of similar age
#10,905
of 344,520 outputs
Outputs of similar age from Nature Communications
#235
of 1,449 outputs
Altmetric has tracked 25,387,480 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 56,487 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 55.7. This one has done well, scoring higher than 84% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 344,520 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 1,449 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 83% of its contemporaries.