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Methylation QTLs in the developing brain and their enrichment in schizophrenia risk loci

Overview of attention for article published in Nature Neuroscience, November 2015
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  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (98th percentile)
  • High Attention Score compared to outputs of the same age and source (83rd percentile)

Mentioned by

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8 news outlets
blogs
4 blogs
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32 X users
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1 patent
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1 Google+ user

Citations

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307 Dimensions

Readers on

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319 Mendeley
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1 CiteULike
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Title
Methylation QTLs in the developing brain and their enrichment in schizophrenia risk loci
Published in
Nature Neuroscience, November 2015
DOI 10.1038/nn.4182
Pubmed ID
Authors

Eilis Hannon, Helen Spiers, Joana Viana, Ruth Pidsley, Joe Burrage, Therese M Murphy, Claire Troakes, Gustavo Turecki, Michael C O'Donovan, Leonard C Schalkwyk, Nicholas J Bray, Jonathan Mill

Abstract

We characterized DNA methylation quantitative trait loci (mQTLs) in a large collection (n = 166) of human fetal brain samples spanning 56-166 d post-conception, identifying >16,000 fetal brain mQTLs. Fetal brain mQTLs were primarily cis-acting, enriched in regulatory chromatin domains and transcription factor binding sites, and showed substantial overlap with genetic variants that were also associated with gene expression in the brain. Using tissue from three distinct regions of the adult brain (prefrontal cortex, striatum and cerebellum), we found that most fetal brain mQTLs were developmentally stable, although a subset was characterized by fetal-specific effects. Fetal brain mQTLs were enriched amongst risk loci identified in a recent large-scale genome-wide association study (GWAS) of schizophrenia, a severe psychiatric disorder with a hypothesized neurodevelopmental component. Finally, we found that mQTLs can be used to refine GWAS loci through the identification of discrete sites of variable fetal brain methylation associated with schizophrenia risk variants.

X Demographics

X Demographics

The data shown below were collected from the profiles of 32 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 319 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 6 2%
United Kingdom 3 <1%
Czechia 1 <1%
Switzerland 1 <1%
China 1 <1%
Canada 1 <1%
Japan 1 <1%
Luxembourg 1 <1%
Unknown 304 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 88 28%
Researcher 63 20%
Student > Master 34 11%
Student > Bachelor 21 7%
Student > Doctoral Student 15 5%
Other 44 14%
Unknown 54 17%
Readers by discipline Count As %
Agricultural and Biological Sciences 85 27%
Biochemistry, Genetics and Molecular Biology 67 21%
Neuroscience 37 12%
Medicine and Dentistry 19 6%
Psychology 11 3%
Other 30 9%
Unknown 70 22%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 105. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 October 2023.
All research outputs
#393,376
of 25,138,857 outputs
Outputs from Nature Neuroscience
#723
of 5,571 outputs
Outputs of similar age
#6,377
of 399,782 outputs
Outputs of similar age from Nature Neuroscience
#15
of 84 outputs
Altmetric has tracked 25,138,857 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,571 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 56.2. This one has done well, scoring higher than 87% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 399,782 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 84 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 83% of its contemporaries.