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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Renal Dosing of Antibiotics: Are We Jumping the Gun?
|
|---|---|
| Published in |
Clinical Infectious Diseases, September 2018
|
| DOI | 10.1093/cid/ciy790 |
| Pubmed ID | |
| Authors |
Ryan L Crass, Keith A Rodvold, Bruce A Mueller, Manjunath P Pai |
| Abstract |
Antibiotic renal dose adjustments are determined in subjects with stable chronic kidney disease and may not translate to patients in late phase trials and practice. Ceftolozane/tazobactam, ceftazidime/avibactam, and telavancin all carry precautionary statements for reduced clinical response in patients with baseline creatinine clearance 30 - 50 mL/min, potentially due to unnecessary dose reduction in the setting of acute kidney injury (AKI). In this review, we discuss the regulatory landscape for antibiotics eliminated by the kidney and highlight the importance of the first 48 hours of therapy. Using a clinical database, we identify AKI on admission in a substantial proportion of patients with pneumonia (27.1%), intra-abdominal (19.5%), urinary tract (20.0%), or skin and skin structure infections (9.7%) that resolved by 48 hours in 57.2% of cases. We suggest that deferred renal dose reduction of wide therapeutic index antibiotics could improve outcomes in patients with infectious diseases. |
X Demographics
The data shown below were collected from the profiles of 406 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 65 | 16% |
| Spain | 52 | 13% |
| Mexico | 16 | 4% |
| Colombia | 12 | 3% |
| Chile | 8 | 2% |
| India | 8 | 2% |
| Canada | 7 | 2% |
| Ecuador | 7 | 2% |
| United Kingdom | 7 | 2% |
| Other | 53 | 13% |
| Unknown | 171 | 42% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 295 | 73% |
| Practitioners (doctors, other healthcare professionals) | 69 | 17% |
| Scientists | 41 | 10% |
| Science communicators (journalists, bloggers, editors) | 1 | <1% |
Mendeley readers
The data shown below were compiled from readership statistics for 127 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 127 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Other | 23 | 18% |
| Researcher | 17 | 13% |
| Student > Ph. D. Student | 10 | 8% |
| Student > Postgraduate | 10 | 8% |
| Student > Master | 10 | 8% |
| Other | 30 | 24% |
| Unknown | 27 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 45 | 35% |
| Pharmacology, Toxicology and Pharmaceutical Science | 18 | 14% |
| Nursing and Health Professions | 5 | 4% |
| Immunology and Microbiology | 5 | 4% |
| Agricultural and Biological Sciences | 3 | 2% |
| Other | 18 | 14% |
| Unknown | 33 | 26% |
Attention Score in Context
This research output has an Altmetric Attention Score of 276. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 April 2024.
All research outputs
#131,902
of 25,774,185 outputs
Outputs from Clinical Infectious Diseases
#340
of 16,964 outputs
Outputs of similar age
#2,581
of 349,054 outputs
Outputs of similar age from Clinical Infectious Diseases
#3
of 222 outputs
Altmetric has tracked 25,774,185 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 16,964 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 31.7. This one has done particularly well, scoring higher than 97% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 349,054 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 222 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 98% of its contemporaries.