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“Salivary gland cellular architecture in the Asian malaria vector mosquito Anopheles stephensi”

Overview of attention for article published in Parasites & Vectors, December 2015
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (67th percentile)
  • Good Attention Score compared to outputs of the same age and source (72nd percentile)

Mentioned by

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7 tweeters
facebook
1 Facebook page

Citations

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12 Dimensions

Readers on

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41 Mendeley
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Title
“Salivary gland cellular architecture in the Asian malaria vector mosquito Anopheles stephensi”
Published in
Parasites & Vectors, December 2015
DOI 10.1186/s13071-015-1229-z
Pubmed ID
Authors

Michael B. Wells, Deborah J. Andrew

Abstract

Anopheles mosquitoes are vectors for malaria, a disease with continued grave outcomes for human health. Transmission of malaria from mosquitoes to humans occurs by parasite passage through the salivary glands (SGs). Previous studies of mosquito SG architecture have been limited in scope and detail. We developed a simple, optimized protocol for fluorescence staining using dyes and/or antibodies to interrogate cellular architecture in Anopheles stephensi adult SGs. We used common biological dyes, antibodies to well-conserved structural and organellar markers, and antibodies against Anopheles salivary proteins to visualize many individual SGs at high resolution by confocal microscopy. These analyses confirmed morphological features previously described using electron microscopy and uncovered a high degree of individual variation in SG structure. Our studies provide evidence for two alternative models for the origin of the salivary duct, the structure facilitating parasite transport out of SGs. We compare SG cellular architecture in An. stephensi and Drosophila melanogaster, a fellow Dipteran whose adult SGs are nearly completely unstudied, and find many conserved features despite divergence in overall form and function. Anopheles salivary proteins previously observed at the basement membrane were localized either in SG cells, secretory cavities, or the SG lumen. Our studies also revealed a population of cells with characteristics consistent with regenerative cells, similar to muscle satellite cells or midgut regenerative cells. This work serves as a foundation for linking Anopheles stephensi SG cellular architecture to function and as a basis for generating and evaluating tools aimed at preventing malaria transmission at the level of mosquito SGs.

Twitter Demographics

The data shown below were collected from the profiles of 7 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 41 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Netherlands 1 2%
Unknown 40 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 9 22%
Student > Master 6 15%
Researcher 5 12%
Student > Postgraduate 4 10%
Student > Doctoral Student 3 7%
Other 5 12%
Unknown 9 22%
Readers by discipline Count As %
Agricultural and Biological Sciences 13 32%
Biochemistry, Genetics and Molecular Biology 5 12%
Environmental Science 3 7%
Immunology and Microbiology 3 7%
Veterinary Science and Veterinary Medicine 2 5%
Other 5 12%
Unknown 10 24%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 July 2016.
All research outputs
#3,174,018
of 8,082,038 outputs
Outputs from Parasites & Vectors
#647
of 2,247 outputs
Outputs of similar age
#94,081
of 297,386 outputs
Outputs of similar age from Parasites & Vectors
#45
of 170 outputs
Altmetric has tracked 8,082,038 research outputs across all sources so far. This one has received more attention than most of these and is in the 60th percentile.
So far Altmetric has tracked 2,247 research outputs from this source. They receive a mean Attention Score of 3.7. This one has gotten more attention than average, scoring higher than 70% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 297,386 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 67% of its contemporaries.
We're also able to compare this research output to 170 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.