Title |
New phenoxazinone-related alkaloids from strain Streptomyces sp. KIB-H1318
|
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Published in |
The Journal of Antibiotics, September 2018
|
DOI | 10.1038/s41429-018-0099-y |
Pubmed ID | |
Authors |
Feng-Xian Yang, Guan-Xiong Hou, Jianying Luo, Jing Yang, Yijun Yan, Sheng-Xiong Huang |
Abstract |
Chemical investigation of a strain Streptomyces sp. KIB-H1318 isolated from soil sample led to the discovery of three new phenoxazinone-related alkaloids 1-3, as well as two known analogs exfoliazone (4) and viridobrunnine A (5). Their structures were determined on the basis of extensive spectroscopic analysis. The antimicrobial activity and cytotoxicity of the isolates were assayed. Exfoliazone and viridobrunnine A exhibited minor antibacterial activity against Escherichia coli ATCC 8099, Bacillus subtilis ATCC 6633, and Staphylococcus aureus ATCC 6538. Compound 2 exhibited low cytotoxicity against two human cancer cell lines HeLa and SW480 with the IC50 values of 36.8 and 37.8 μM, respectively. |
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Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 17% |
Pakistan | 1 | 17% |
United States | 1 | 17% |
Nigeria | 1 | 17% |
Unknown | 2 | 33% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 4 | 67% |
Science communicators (journalists, bloggers, editors) | 1 | 17% |
Scientists | 1 | 17% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 15 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 4 | 27% |
Lecturer | 2 | 13% |
Student > Master | 2 | 13% |
Student > Doctoral Student | 1 | 7% |
Other | 1 | 7% |
Other | 1 | 7% |
Unknown | 4 | 27% |
Readers by discipline | Count | As % |
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Pharmacology, Toxicology and Pharmaceutical Science | 3 | 20% |
Medicine and Dentistry | 2 | 13% |
Veterinary Science and Veterinary Medicine | 1 | 7% |
Biochemistry, Genetics and Molecular Biology | 1 | 7% |
Unspecified | 1 | 7% |
Other | 2 | 13% |
Unknown | 5 | 33% |