Title |
The complement system in glioblastoma multiforme
|
---|---|
Published in |
Acta Neuropathologica Communications, September 2018
|
DOI | 10.1186/s40478-018-0591-4 |
Pubmed ID | |
Authors |
T. A. M. Bouwens van der Vlis, J. M. Kros, D. A. M. Mustafa, R. T. A. van Wijck, L. Ackermans, P. M. van Hagen, P. J. van der Spek |
Abstract |
The human complement system is represents the main effector arm of innate immunity and its ambivalent function in cancer has been subject of ongoing dispute. Glioma stem-like cells (GSC) residing in specific niches within glioblastomas (GBM) are capable of self-renewal and tumor proliferation. Recent data are indicative of the influence of the complement system on the maintenance of these cells. It appears that the role of the complement system in glial tumorigenesis, particularly its influence on GSC niches and GSC maintenance, is significant and warrants further exploration for therapeutic interventions. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Spain | 1 | 25% |
Unknown | 3 | 75% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 3 | 75% |
Practitioners (doctors, other healthcare professionals) | 1 | 25% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 49 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 6 | 12% |
Student > Doctoral Student | 6 | 12% |
Student > Bachelor | 6 | 12% |
Researcher | 4 | 8% |
Student > Master | 4 | 8% |
Other | 8 | 16% |
Unknown | 15 | 31% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 11 | 22% |
Medicine and Dentistry | 6 | 12% |
Immunology and Microbiology | 3 | 6% |
Neuroscience | 2 | 4% |
Chemistry | 2 | 4% |
Other | 6 | 12% |
Unknown | 19 | 39% |