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The effects of probiotic and selenium co-supplementation on parameters of mental health, hormonal profiles, and biomarkers of inflammation and oxidative stress in women with polycystic ovary syndrome

Overview of attention for article published in Journal of Ovarian Research, September 2018
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (64th percentile)

Mentioned by

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7 tweeters
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2 Facebook pages

Citations

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19 Dimensions

Readers on

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107 Mendeley
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Title
The effects of probiotic and selenium co-supplementation on parameters of mental health, hormonal profiles, and biomarkers of inflammation and oxidative stress in women with polycystic ovary syndrome
Published in
Journal of Ovarian Research, September 2018
DOI 10.1186/s13048-018-0457-1
Pubmed ID
Authors

Mehri Jamilian, Shirin Mansury, Fereshteh Bahmani, Zahra Heidar, Elaheh Amirani, Zatollah Asemi

Abstract

The aim of this study was to evaluate the effect of the co-administration of probiotic and selenium on parameters of mental health, hormonal profiles, and biomarkers of inflammation and oxidative stress in women with PCOS. Data on the effects of selenium and probiotic co-supplementation on mental health, hormonal and inflammatory parameters of patients with polycystic ovary syndrome (PCOS) are scarce. This investigation was carried out to evaluate the effects of selenium and probiotic co-supplementation on mental health, hormonal and inflammatory parameters in women with PCOS. This randomized, double-blinded, placebo-controlled clinical trial was conducted on 60 subjects, aged 18-40 years old. Participants were randomly allocated into two groups to intake 8 × 109 CFU/day probiotic plus 200 μg/day selenium supplements (n = 30) or placebo (n = 30) for 12 weeks. Hormonal and inflammatory parameters were measured at baseline and after the 12-week intervention. Probiotic and selenium co-supplementation resulted in a significant improvement in beck depression inventory (β - 0.76; 95% CI, - 1.26, - 0.26; P = 0.003), general health questionnaire scores (β - 1.15; 95% CI, - 1.97, - 0.32; P = 0.007) and depression anxiety and stress scale scores (β - 1.49; 95% CI, - 2.59, - 0.39; P = 0.009) compared with the placebo. Furthermore, probiotic and selenium co-supplementation significantly reduced total testosterone (β - 0.26 ng/mL; 95% CI, - 0.51, - 0.02; P = 0.03), hirsutism (β - 0.43; 95% CI, - 0.74, - 0.11; P = 0.008), high-sensitivity C-reactive protein (hs-CRP) (β - 0.58 mg/L; 95% CI, - 0.97, - 0.19; P = 0.004) and malondialdehyde (MDA) levels (β - 0.29 μmol/L; 95% CI, - 0.56, - 0.02; P = 0.03), and significantly increased total antioxidant capacity (TAC) (β + 84.76 mmol/L; 95% CI, + 48.08, + 121.44; P < 0.001) and total glutathione (GSH) levels (β + 26.78 μmol/L; 95% CI, + 4.33, + 49.23; P = 0.02) compared with the placebo. Overall, the co-administration of probiotic and selenium for 12 weeks to women with PCOS had beneficial effects on mental health parameters, serum total testosterone, hirsutism, hs-CRP, TAC, GSH and MDA levels. This study was prospectively registered in the Iranian website ( www.irct.ir ) for registration of clinical trials ( http://www.irct.ir : IRCT20170513033941N22). IRCT20170513033941N22 .

Twitter Demographics

The data shown below were collected from the profiles of 7 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 107 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 107 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 27 25%
Student > Master 19 18%
Student > Doctoral Student 10 9%
Researcher 9 8%
Student > Ph. D. Student 9 8%
Other 9 8%
Unknown 24 22%
Readers by discipline Count As %
Medicine and Dentistry 32 30%
Nursing and Health Professions 20 19%
Pharmacology, Toxicology and Pharmaceutical Science 5 5%
Psychology 5 5%
Agricultural and Biological Sciences 4 4%
Other 11 10%
Unknown 30 28%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 April 2019.
All research outputs
#4,662,391
of 16,126,328 outputs
Outputs from Journal of Ovarian Research
#51
of 380 outputs
Outputs of similar age
#81,790
of 231,181 outputs
Outputs of similar age from Journal of Ovarian Research
#1
of 1 outputs
Altmetric has tracked 16,126,328 research outputs across all sources so far. This one has received more attention than most of these and is in the 70th percentile.
So far Altmetric has tracked 380 research outputs from this source. They receive a mean Attention Score of 2.8. This one has done well, scoring higher than 86% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 231,181 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 64% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them