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MDA5-positive dermatomyositis: an uncommon entity in Europe with variable clinical presentations

Overview of attention for article published in Clinical and Molecular Allergy, November 2015
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  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (80th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (62nd percentile)

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Title
MDA5-positive dermatomyositis: an uncommon entity in Europe with variable clinical presentations
Published in
Clinical and Molecular Allergy, November 2015
DOI 10.1186/s12948-015-0031-y
Pubmed ID
Authors

Paola Parronchi, Anna Radice, Boaz Palterer, Francesco Liotta, Cristina Scaletti

Abstract

Clinically amyopathic dermatomyositis (CADM), described almost 50 years ago, is defined on the basis of still not validated criteria and characterized by skin findings almost without muscle weakness. Autoantibodies directed against the cytosolic pathogen sensor MDA5 (CADM 140) can mark this subtype of dermatomyositis which has been reported to associate, in particular ethnic groups, with severe progressive interstitial lung disease, poor prognosis and an hyperferritinemic status resembling hemophagocytic-like syndromes. MDA5 may be relevant in that Interferon-signature claimed to characterize inflammatory myopathies and dermatomyosits itself, but its role is not clear. However, the titre of anti-MDA5 autoantibodies seems to correlate with the outcome. In Caucasian populations the association between anti-MDA5 positive CADM and rapidly progressive interstitial lung disease seems to be weaker, but the limited numbers of patients described so far could explain the lack of statistical significance. As a fact, European patients with circulating anti-MDA5 autoantibodies may be clinically inhomogeneous and exhibit different rates of severity. The two patients affected by anti-MDA5 positive dermatomyositis described hereafter provide a clear example of the extreme variability of the disease in terms of laboratory findings and clinical features.

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X Demographics

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 57 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Belgium 1 2%
Unknown 56 98%

Demographic breakdown

Readers by professional status Count As %
Student > Postgraduate 11 19%
Student > Ph. D. Student 6 11%
Student > Bachelor 6 11%
Researcher 6 11%
Other 5 9%
Other 13 23%
Unknown 10 18%
Readers by discipline Count As %
Medicine and Dentistry 34 60%
Nursing and Health Professions 3 5%
Neuroscience 3 5%
Immunology and Microbiology 2 4%
Biochemistry, Genetics and Molecular Biology 2 4%
Other 3 5%
Unknown 10 18%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 8. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 February 2022.
All research outputs
#4,027,643
of 23,153,849 outputs
Outputs from Clinical and Molecular Allergy
#66
of 214 outputs
Outputs of similar age
#55,244
of 285,656 outputs
Outputs of similar age from Clinical and Molecular Allergy
#3
of 8 outputs
Altmetric has tracked 23,153,849 research outputs across all sources so far. Compared to these this one has done well and is in the 82nd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 214 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.1. This one has gotten more attention than average, scoring higher than 65% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 285,656 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 80% of its contemporaries.
We're also able to compare this research output to 8 others from the same source and published within six weeks on either side of this one. This one has scored higher than 5 of them.