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The Role of the Brain's Endocannabinoid System in Pain and Its Modulation by Stress.

Overview of attention for article published in International review of neurobiology, January 2015
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1 tweeter
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2 Facebook pages

Citations

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25 Dimensions

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93 Mendeley
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Title
The Role of the Brain's Endocannabinoid System in Pain and Its Modulation by Stress.
Published in
International review of neurobiology, January 2015
DOI 10.1016/bs.irn.2015.10.003
Pubmed ID
Authors

Corcoran, Louise, Roche, Michelle, Finn, David P

Abstract

Stress has a complex, bidirectional modulatory influence on pain. Stress may either reduce (stress-induced analgesia) or exacerbate (stress-induced hyperalgesia) pain depending on the nature, duration, and intensity of the stressor. The endogenous cannabinoid (endocannabinoid) system is present throughout the neuroanatomical pathways that mediate and modulate responses to painful stimuli. The specific role of the endocannabinoid system in the brain in pain and the modulation of pain by stress is reviewed herein. We first provide a brief overview of the endocannabinoid system, followed by a review of the evidence that the brain's endocannabinoid system modulates pain. We provide a comprehensive evaluation of the role of the endocannabinoid system supraspinally, and particularly in the rostral ventromedial medulla, periaqueductal gray, amygdala, and prefrontal cortex, in pain, stress-induced analgesia, and stress-induced hyperalgesia. Increased understanding of endocannabinoid-mediated regulation of pain and its modulation by stress will inform the development of novel therapeutic approaches for pain and its comorbidity with stress-related disorders.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 93 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 93 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 16 17%
Student > Bachelor 14 15%
Researcher 13 14%
Student > Master 11 12%
Student > Doctoral Student 8 9%
Other 19 20%
Unknown 12 13%
Readers by discipline Count As %
Medicine and Dentistry 20 22%
Neuroscience 17 18%
Psychology 8 9%
Biochemistry, Genetics and Molecular Biology 7 8%
Agricultural and Biological Sciences 7 8%
Other 16 17%
Unknown 18 19%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 December 2015.
All research outputs
#10,323,549
of 16,175,903 outputs
Outputs from International review of neurobiology
#326
of 498 outputs
Outputs of similar age
#197,746
of 369,447 outputs
Outputs of similar age from International review of neurobiology
#24
of 39 outputs
Altmetric has tracked 16,175,903 research outputs across all sources so far. This one is in the 23rd percentile – i.e., 23% of other outputs scored the same or lower than it.
So far Altmetric has tracked 498 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.9. This one is in the 25th percentile – i.e., 25% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 369,447 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 36th percentile – i.e., 36% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 39 others from the same source and published within six weeks on either side of this one. This one is in the 25th percentile – i.e., 25% of its contemporaries scored the same or lower than it.