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X Demographics
Mendeley readers
Attention Score in Context
| Title |
EPPS rescues hippocampus-dependent cognitive deficits in APP/PS1 mice by disaggregation of amyloid-β oligomers and plaques
|
|---|---|
| Published in |
Nature Communications, December 2015
|
| DOI | 10.1038/ncomms9997 |
| Pubmed ID | |
| Authors |
Hye Yun Kim, Hyunjin Vincent Kim, Seonmi Jo, C. Justin Lee, Seon Young Choi, Dong Jin Kim, YoungSoo Kim |
| Abstract |
Alzheimer's disease (AD) is characterized by the transition of amyloid-β (Aβ) monomers into toxic oligomers and plaques. Given that Aβ abnormality typically precedes the development of clinical symptoms, an agent capable of disaggregating existing Aβ aggregates may be advantageous. Here we report that a small molecule, 4-(2-hydroxyethyl)-1-piperazinepropanesulphonic acid (EPPS), binds to Aβ aggregates and converts them into monomers. The oral administration of EPPS substantially reduces hippocampus-dependent behavioural deficits, brain Aβ oligomer and plaque deposits, glial γ-aminobutyric acid (GABA) release and brain inflammation in an Aβ-overexpressing, APP/PS1 transgenic mouse model when initiated after the development of severe AD-like phenotypes. The ability of EPPS to rescue Aβ aggregation and behavioural deficits provides strong support for the view that the accumulation of Aβ is an important mechanism underlying AD. |
X Demographics
The data shown below were collected from the profiles of 162 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 30 | 19% |
| United Kingdom | 10 | 6% |
| Spain | 8 | 5% |
| India | 7 | 4% |
| Turkey | 5 | 3% |
| Ireland | 4 | 2% |
| Germany | 3 | 2% |
| Italy | 3 | 2% |
| France | 3 | 2% |
| Other | 23 | 14% |
| Unknown | 66 | 41% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 146 | 90% |
| Scientists | 11 | 7% |
| Practitioners (doctors, other healthcare professionals) | 4 | 2% |
| Science communicators (journalists, bloggers, editors) | 1 | <1% |
Mendeley readers
The data shown below were compiled from readership statistics for 214 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | <1% |
| Canada | 1 | <1% |
| Finland | 1 | <1% |
| Spain | 1 | <1% |
| Korea, Republic of | 1 | <1% |
| Unknown | 208 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 46 | 21% |
| Researcher | 41 | 19% |
| Student > Master | 23 | 11% |
| Student > Bachelor | 22 | 10% |
| Other | 17 | 8% |
| Other | 42 | 20% |
| Unknown | 23 | 11% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 44 | 21% |
| Neuroscience | 37 | 17% |
| Biochemistry, Genetics and Molecular Biology | 29 | 14% |
| Chemistry | 20 | 9% |
| Pharmacology, Toxicology and Pharmaceutical Science | 12 | 6% |
| Other | 41 | 19% |
| Unknown | 31 | 14% |
Attention Score in Context
This research output has an Altmetric Attention Score of 328. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 January 2023.
All research outputs
#102,699
of 25,579,912 outputs
Outputs from Nature Communications
#1,496
of 57,695 outputs
Outputs of similar age
#1,469
of 396,514 outputs
Outputs of similar age from Nature Communications
#16
of 678 outputs
Altmetric has tracked 25,579,912 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 57,695 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 55.5. This one has done particularly well, scoring higher than 97% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 396,514 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 678 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.