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Emergence of HIV-1 drug resistance mutations in mothers on treatment with a history of prophylaxis in Ghana

Overview of attention for article published in Virology Journal, September 2018
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  • Above-average Attention Score compared to outputs of the same age (55th percentile)

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3 tweeters

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22 Mendeley
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Title
Emergence of HIV-1 drug resistance mutations in mothers on treatment with a history of prophylaxis in Ghana
Published in
Virology Journal, September 2018
DOI 10.1186/s12985-018-1051-2
Pubmed ID
Authors

Alexander Martin-Odoom, Charles Addoquaye Brown, John Kofi Odoom, Evelyn Yayra Bonney, Nana Afia Asante Ntim, Elena Delgado, Margaret Lartey, Kwamena William Sagoe, Theophilus Adiku, William Kwabena Ampofo

Abstract

Antiretrovirals have been available in Ghana since 2003 for HIV-1 positive pregnant women for prevention of mother-to-child transmission (PMTCT). Suboptimal responses to treatment observed post-PMTCT interventions necessitated the need to investigate the profile of viral mutations generated. This study investigated HIV-1 drug resistance profiles in mothers in selected centres in Ghana on treatment with a history of prophylaxis. Genotypic Drug Resistance Testing for HIV-1 was carried out. Subtyping was done by phylogenetic analysis and Stanford HIV Database programme was used for drug resistance analysis and interpretation. To compare the significance between the different groups and the emergence of drug resistance mutations, p values were used. Participants who had prophylaxis before treatment, those who had treatment without prophylaxis and those yet to initiate PMTCT showed 32% (8), 5% (3) and 15% (4) HIV-1 drug resistance associated mutations respectively. The differences were significant with p value < 0.05. Resistance Associated Mutations (RAMs) were seen in 14 participants (35%) to nucleoside reverse transcriptase inhibitors (NRTIs) and non-nucleoside reverse transcriptase inhibitors (NNRTIs). The most common NRTI mutation found was M184 V; K103 N and A98G were the most common NNRTI mutations seen. Thymidine Analogue Mutations (TAMs) such as M41 L, K70R and T215Y were found in all the groups; the most common of the TAMs found were M41 L and T215Y. Majority of the subtypes were CRF02_AG (82%). In Ghana initiation of uninterrupted treatment upon diagnosis, coupled with drug resistance testing, would produce a better treatment outcome for HIV-1 positive pregnant women.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 22 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 22 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 9 41%
Unspecified 4 18%
Student > Master 4 18%
Student > Postgraduate 2 9%
Student > Doctoral Student 1 5%
Other 2 9%
Readers by discipline Count As %
Medicine and Dentistry 7 32%
Unspecified 5 23%
Biochemistry, Genetics and Molecular Biology 3 14%
Agricultural and Biological Sciences 2 9%
Immunology and Microbiology 2 9%
Other 3 14%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 September 2018.
All research outputs
#6,796,393
of 12,662,942 outputs
Outputs from Virology Journal
#845
of 2,113 outputs
Outputs of similar age
#118,207
of 264,245 outputs
Outputs of similar age from Virology Journal
#1
of 1 outputs
Altmetric has tracked 12,662,942 research outputs across all sources so far. This one is in the 46th percentile – i.e., 46% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,113 research outputs from this source. They receive a mean Attention Score of 3.5. This one has gotten more attention than average, scoring higher than 59% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 264,245 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 55% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them