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Comparative genomics of Pseudomonas fluorescens subclade III strains from human lungs

Overview of attention for article published in BMC Genomics, December 2015
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  • Above-average Attention Score compared to outputs of the same age (59th percentile)
  • Average Attention Score compared to outputs of the same age and source

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3 tweeters

Citations

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4 Dimensions

Readers on

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33 Mendeley
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Title
Comparative genomics of Pseudomonas fluorescens subclade III strains from human lungs
Published in
BMC Genomics, December 2015
DOI 10.1186/s12864-015-2261-2
Pubmed ID
Authors

Brittan S. Scales, John R. Erb-Downward, Ian M. Huffnagle, John J. LiPuma, Gary B. Huffnagle

Abstract

While the taxonomy and genomics of environmental strains from the P. fluorescens species-complex has been reported, little is known about P. fluorescens strains from clinical samples. In this report, we provide the first genomic analysis of P. fluorescens strains in which human vs. environmental isolates are compared. Seven P. fluorescens strains were isolated from respiratory samples from cystic fibrosis (CF) patients. The clinical strains could grow at a higher temperature (>34 °C) than has been reported for environmental strains. Draft genomes were generated for all of the clinical strains, and multi-locus sequence analysis placed them within subclade III of the P. fluorescens species-complex. All strains encoded type- II, -III, -IV, and -VI secretion systems, as well as the widespread colonization island (WCI). This is the first description of a WCI in P. fluorescens strains. All strains also encoded a complete I2/PfiT locus and showed evidence of horizontal gene transfer. The clinical strains were found to differ from the environmental strains in the number of genes involved in metal resistance, which may be a possible adaptation to chronic antibiotic exposure in the CF lung. This is the largest comparative genomics analysis of P. fluorescens subclade III strains to date and includes the first clinical isolates. At a global level, the clinical P. fluorescens subclade III strains were largely indistinguishable from environmental P. fluorescens subclade III strains, supporting the idea that identifying strains as 'environmental' vs 'clinical' is not a phenotypic trait. Rather, strains within P. fluorescens subclade III will colonize and persist in any niche that provides the requirements necessary for growth.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 33 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 33 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 7 21%
Researcher 5 15%
Student > Master 4 12%
Student > Doctoral Student 4 12%
Student > Bachelor 4 12%
Other 5 15%
Unknown 4 12%
Readers by discipline Count As %
Agricultural and Biological Sciences 10 30%
Biochemistry, Genetics and Molecular Biology 6 18%
Medicine and Dentistry 5 15%
Immunology and Microbiology 5 15%
Computer Science 1 3%
Other 1 3%
Unknown 5 15%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 December 2015.
All research outputs
#2,710,694
of 6,717,285 outputs
Outputs from BMC Genomics
#2,577
of 5,225 outputs
Outputs of similar age
#110,240
of 282,435 outputs
Outputs of similar age from BMC Genomics
#203
of 359 outputs
Altmetric has tracked 6,717,285 research outputs across all sources so far. This one has received more attention than most of these and is in the 58th percentile.
So far Altmetric has tracked 5,225 research outputs from this source. They receive a mean Attention Score of 4.0. This one is in the 47th percentile – i.e., 47% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 282,435 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 59% of its contemporaries.
We're also able to compare this research output to 359 others from the same source and published within six weeks on either side of this one. This one is in the 37th percentile – i.e., 37% of its contemporaries scored the same or lower than it.