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Assessing quality and completeness of human transcriptional regulatory pathways on a genome-wide scale

Overview of attention for article published in Biology Direct, February 2011
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (91st percentile)

Mentioned by

blogs
1 blog
twitter
3 X users
patent
2 patents

Citations

dimensions_citation
47 Dimensions

Readers on

mendeley
112 Mendeley
citeulike
4 CiteULike
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Title
Assessing quality and completeness of human transcriptional regulatory pathways on a genome-wide scale
Published in
Biology Direct, February 2011
DOI 10.1186/1745-6150-6-15
Pubmed ID
Authors

Evgeny Shmelkov, Zuojian Tang, Iannis Aifantis, Alexander Statnikov

Abstract

Pathway databases are becoming increasingly important and almost omnipresent in most types of biological and translational research. However, little is known about the quality and completeness of pathways stored in these databases. The present study conducts a comprehensive assessment of transcriptional regulatory pathways in humans for seven well-studied transcription factors: MYC, NOTCH1, BCL6, TP53, AR, STAT1, and RELA. The employed benchmarking methodology first involves integrating genome-wide binding with functional gene expression data to derive direct targets of transcription factors. Then the lists of experimentally obtained direct targets are compared with relevant lists of transcriptional targets from 10 commonly used pathway databases.

X Demographics

X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 112 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 4 4%
Germany 3 3%
Belgium 2 2%
United States 2 2%
India 1 <1%
Brazil 1 <1%
Netherlands 1 <1%
China 1 <1%
Turkey 1 <1%
Other 2 2%
Unknown 94 84%

Demographic breakdown

Readers by professional status Count As %
Researcher 45 40%
Student > Ph. D. Student 21 19%
Student > Master 12 11%
Other 7 6%
Professor 5 4%
Other 14 13%
Unknown 8 7%
Readers by discipline Count As %
Agricultural and Biological Sciences 58 52%
Biochemistry, Genetics and Molecular Biology 11 10%
Computer Science 8 7%
Medicine and Dentistry 8 7%
Immunology and Microbiology 7 6%
Other 9 8%
Unknown 11 10%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 15. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 January 2021.
All research outputs
#2,306,638
of 25,263,619 outputs
Outputs from Biology Direct
#88
of 534 outputs
Outputs of similar age
#9,387
of 114,664 outputs
Outputs of similar age from Biology Direct
#1
of 1 outputs
Altmetric has tracked 25,263,619 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 534 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.4. This one has done well, scoring higher than 83% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 114,664 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 91% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them