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The functional diversity of Aurora kinases: a comprehensive review

Overview of attention for article published in Cell Division, September 2018
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (51st percentile)

Mentioned by

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3 tweeters

Citations

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16 Dimensions

Readers on

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77 Mendeley
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Title
The functional diversity of Aurora kinases: a comprehensive review
Published in
Cell Division, September 2018
DOI 10.1186/s13008-018-0040-6
Pubmed ID
Authors

Estelle Willems, Matthias Dedobbeleer, Marina Digregorio, Arnaud Lombard, Paul Noel Lumapat, Bernard Rogister

Abstract

Aurora kinases are serine/threonine kinases essential for the onset and progression of mitosis. Aurora members share a similar protein structure and kinase activity, but exhibit distinct cellular and subcellular localization. AurA favors the G2/M transition by promoting centrosome maturation and mitotic spindle assembly. AurB and AurC are chromosome-passenger complex proteins, crucial for chromosome binding to kinetochores and segregation of chromosomes. Cellular distribution of AurB is ubiquitous, while AurC expression is mainly restricted to meiotically-active germ cells. In human tumors, all Aurora kinase members play oncogenic roles related to their mitotic activity and promote cancer cell survival and proliferation. Furthermore, AurA plays tumor-promoting roles unrelated to mitosis, including tumor stemness, epithelial-to-mesenchymal transition and invasion. In this review, we aim to understand the functional interplay of Aurora kinases in various types of human cells, including tumor cells. The understanding of the functional diversity of Aurora kinases could help to evaluate their relevance as potential therapeutic targets in cancer.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 77 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 77 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 27 35%
Student > Master 11 14%
Student > Bachelor 9 12%
Researcher 7 9%
Student > Doctoral Student 5 6%
Other 8 10%
Unknown 10 13%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 29 38%
Agricultural and Biological Sciences 17 22%
Chemistry 6 8%
Medicine and Dentistry 5 6%
Immunology and Microbiology 3 4%
Other 5 6%
Unknown 12 16%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 September 2018.
All research outputs
#7,326,911
of 13,560,184 outputs
Outputs from Cell Division
#40
of 87 outputs
Outputs of similar age
#123,156
of 266,040 outputs
Outputs of similar age from Cell Division
#1
of 1 outputs
Altmetric has tracked 13,560,184 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 87 research outputs from this source. They receive a mean Attention Score of 3.1. This one has gotten more attention than average, scoring higher than 54% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 266,040 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 51% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them