| Chapter title |
Novel Biomarkers for Prostate Cancer Detection and Prognosis
|
|---|---|
| Chapter number | 2 |
| Book title |
Cell & Molecular Biology of Prostate Cancer
|
| Published in |
Advances in experimental medicine and biology, September 2018
|
| DOI | 10.1007/978-3-319-95693-0_2 |
| Pubmed ID | |
| Book ISBNs |
978-3-31-995692-3, 978-3-31-995693-0
|
| Authors |
Xavier Filella, Laura Foj, Filella, Xavier, Foj, Laura |
| Abstract |
Prostate cancer (PCa) remains as one of the most controversial issues in health care because of the dilemmas related to screening using Prostate Specific Antigen (PSA). A high number of false positive biopsies and an elevated rate of overdiagnosis are the main problems associated with PSA. New PCa biomarkers have been recently proposed to increase the predictive value of PSA. The published results showed that PCA3 score, Prostate Health Index and 4Kscore can reduce the number of unnecessary biopsies, outperforming better than PSA and the percentage of free PSA. Furthermore, 4Kscore provides with high accuracy an individual risk for high-grade PCa. High values of PHI are also associated with tumor aggressiveness. In contrast, the relationship of PCA3 score with aggressiveness remains controversial, with studies showing opposite conclusions. Finally, the development of molecular biology has opened the study of genes, among them TMPRSS2:ERG fusion gene and miRNAs, in PCa detection and prognosis. |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 34 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 5 | 15% |
| Student > Bachelor | 4 | 12% |
| Researcher | 4 | 12% |
| Student > Ph. D. Student | 3 | 9% |
| Student > Postgraduate | 2 | 6% |
| Other | 4 | 12% |
| Unknown | 12 | 35% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 6 | 18% |
| Biochemistry, Genetics and Molecular Biology | 5 | 15% |
| Immunology and Microbiology | 3 | 9% |
| Linguistics | 1 | 3% |
| Veterinary Science and Veterinary Medicine | 1 | 3% |
| Other | 3 | 9% |
| Unknown | 15 | 44% |