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Structure and function of neonatal social communication in a genetic mouse model of autism

Overview of attention for article published in Molecular Psychiatry, December 2015
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (88th percentile)
  • Average Attention Score compared to outputs of the same age and source

Mentioned by

news
1 news outlet
twitter
6 tweeters

Citations

dimensions_citation
47 Dimensions

Readers on

mendeley
87 Mendeley
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Title
Structure and function of neonatal social communication in a genetic mouse model of autism
Published in
Molecular Psychiatry, December 2015
DOI 10.1038/mp.2015.190
Pubmed ID
Authors

T Takahashi, S Okabe, P Ó Broin, A Nishi, K Ye, M V Beckert, T Izumi, A Machida, G Kang, S Abe, J L Pena, A Golden, T Kikusui, N Hiroi

Abstract

A critical step toward understanding autism spectrum disorder (ASD) is to identify both genetic and environmental risk factors. A number of rare copy number variants (CNVs) have emerged as robust genetic risk factors for ASD, but not all CNV carriers exhibit ASD and the severity of ASD symptoms varies among CNV carriers. Although evidence exists that various environmental factors modulate symptomatic severity, the precise mechanisms by which these factors determine the ultimate severity of ASD are still poorly understood. Here, using a mouse heterozygous for Tbx1 (a gene encoded in 22q11.2 CNV), we demonstrate that a genetically triggered neonatal phenotype in vocalization generates a negative environmental loop in pup-mother social communication. Wild-type pups used individually diverse sequences of simple and complicated call types, but heterozygous pups used individually invariable call sequences with less complicated call types. When played back, representative wild-type call sequences elicited maternal approach, but heterozygous call sequences were ineffective. When the representative wild-type call sequences were randomized, they were ineffective in eliciting vigorous maternal approach behavior. These data demonstrate that an ASD risk gene alters the neonatal call sequence of its carriers and this pup phenotype in turn diminishes maternal care through atypical social communication. Thus, an ASD risk gene induces, through atypical neonatal call sequences, less than optimal maternal care as a negative neonatal environmental factor.Molecular Psychiatry advance online publication, 15 December 2015; doi:10.1038/mp.2015.190.

Twitter Demographics

The data shown below were collected from the profiles of 6 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 87 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 3 3%
Japan 2 2%
Canada 1 1%
Unknown 81 93%

Demographic breakdown

Readers by professional status Count As %
Researcher 21 24%
Student > Ph. D. Student 20 23%
Student > Master 11 13%
Student > Bachelor 8 9%
Student > Postgraduate 4 5%
Other 15 17%
Unknown 8 9%
Readers by discipline Count As %
Neuroscience 20 23%
Psychology 18 21%
Agricultural and Biological Sciences 11 13%
Medicine and Dentistry 9 10%
Biochemistry, Genetics and Molecular Biology 3 3%
Other 10 11%
Unknown 16 18%

Attention Score in Context

This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 December 2015.
All research outputs
#1,772,861
of 16,373,991 outputs
Outputs from Molecular Psychiatry
#1,161
of 3,137 outputs
Outputs of similar age
#44,474
of 372,467 outputs
Outputs of similar age from Molecular Psychiatry
#35
of 59 outputs
Altmetric has tracked 16,373,991 research outputs across all sources so far. Compared to these this one has done well and is in the 89th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,137 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 29.3. This one has gotten more attention than average, scoring higher than 62% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 372,467 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 88% of its contemporaries.
We're also able to compare this research output to 59 others from the same source and published within six weeks on either side of this one. This one is in the 40th percentile – i.e., 40% of its contemporaries scored the same or lower than it.