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Effects of morphine on the expression of cytokines and inflammatory mediators in a rabbit model of endotoxin-induced experimental uveitis

Overview of attention for article published in Arquivos Brasileiros de Oftalmologia, January 2015
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Title
Effects of morphine on the expression of cytokines and inflammatory mediators in a rabbit model of endotoxin-induced experimental uveitis
Published in
Arquivos Brasileiros de Oftalmologia, January 2015
DOI 10.5935/0004-2749.20150098
Pubmed ID
Authors

Kethye P. Ortencio, Roberta Renzo, Alexandre A. F. B. Sobrinho, Karina Kamachi Kobashigawa, Roberta M. Crivelaro, Germana A. Silva, Marcela Aldrovani, Alexandre Pinto Ribeiro, Tiago W. P. Mineo, José Luiz Laus

Abstract

To evaluate the effects of 1% morphine instillation on clinical parameters, aqueous humor turbidity, and expression levels of tumor necrosis factor alpha (TNF-α), interleukin-1 beta (IL-1beta), prostaglandin E2 (PGE2), and myeloperoxidase (MPO) in rabbits with endotoxin-induced experimental uveitis. Twenty four New Zealand white rabbits were divided into four groups (n=6 each): control (CG), morphine (MG), naloxone (NG), and morphine-naloxone (MNG) groups. Under dissociative anesthesia, 0.1 mL of solution containing 0.2 µg of lipopolysaccharide (LPS) endotoxin from the Salmonella typhimurium cell wall was injected in the vitreous chamber. Clinical evaluations (conjunctical hyperemia, chemosis blepharospasm, and ocular discharge) and laser flaremetry were performed before (baseline), and 10 and 20 hours after induction of uveitis. Rabbits were subsequently euthanized and eyes were enucleated to quantify expression levels of TNF-α, IL-1 beta, PGE2, and MPO. No significant differences in clinical parameters and flare values were observed between the study groups. TNF-α and IL-1 beta levels increased significantly in the CG, MG, NG, and MNG groups compared to baseline (P<0.05). Significant differences in PGE2 levels were observed between the MG and NMG groups (P<0.05). A trend toward increased MPO activity was observed in response to uveitis induction; however, this trend did not reach statistical significance (P>0.05). Morphine has no effect on clinical parameters, flare, or expression levels of inflammatory mediators in a rabbit model of uveitis induced by intravitreal injection of LPS.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 14 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 14 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 4 29%
Student > Doctoral Student 3 21%
Student > Bachelor 2 14%
Other 2 14%
Professor 1 7%
Other 0 0%
Unknown 2 14%
Readers by discipline Count As %
Medicine and Dentistry 8 57%
Biochemistry, Genetics and Molecular Biology 1 7%
Pharmacology, Toxicology and Pharmaceutical Science 1 7%
Immunology and Microbiology 1 7%
Veterinary Science and Veterinary Medicine 1 7%
Other 0 0%
Unknown 2 14%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 December 2015.
All research outputs
#9,983,274
of 12,471,795 outputs
Outputs from Arquivos Brasileiros de Oftalmologia
#104
of 166 outputs
Outputs of similar age
#234,030
of 343,849 outputs
Outputs of similar age from Arquivos Brasileiros de Oftalmologia
#13
of 30 outputs
Altmetric has tracked 12,471,795 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 166 research outputs from this source. They receive a mean Attention Score of 1.8. This one is in the 32nd percentile – i.e., 32% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 343,849 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 18th percentile – i.e., 18% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 30 others from the same source and published within six weeks on either side of this one. This one is in the 43rd percentile – i.e., 43% of its contemporaries scored the same or lower than it.