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HLA-A is a Predictor of Hepatitis B e Antigen Status in HIV-Positive African Adults

Overview of attention for article published in Journal of Infectious Diseases, December 2015
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2 tweeters

Citations

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4 Dimensions

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37 Mendeley
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Title
HLA-A is a Predictor of Hepatitis B e Antigen Status in HIV-Positive African Adults
Published in
Journal of Infectious Diseases, December 2015
DOI 10.1093/infdis/jiv592
Pubmed ID
Authors

Philippa C. Matthews, Jonathan M. Carlson, Apostolos Beloukas, Amna Malik, Pieter Jooste, Anthony Ogwu, Roger Shapiro, Lynn Riddell, Fabian Chen, Graz Luzzi, Gerald Jesuthasan, Katie Jeffery, Nebojsa Jojic, Thumbi Ndung'u, Mary Carrington, Philip J. R. Goulder, Anna Maria Geretti, Paul Klenerman

Abstract

Outcomes of chronic infection with hepatitis B virus (HBV) are varied, with increased morbidity reported in the context of HIV coinfection. The factors driving different outcomes are not well understood, but there is increasing interest in an HLA Class I effect. We therefore studied the influence of HLA class I on HBV in an African HIV-positive cohort. We demonstrated that virologic markers of HBV disease activity (HBeAg status / HBV DNA level) are associated with HLA-A genotype. This finding supports the role of the CD8+ T cell response in HBV control, and potentially informs future therapeutic T cell vaccine strategies.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 37 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
South Africa 1 3%
Unknown 36 97%

Demographic breakdown

Readers by professional status Count As %
Researcher 12 32%
Student > Ph. D. Student 7 19%
Student > Master 4 11%
Student > Postgraduate 4 11%
Unspecified 4 11%
Other 6 16%
Readers by discipline Count As %
Medicine and Dentistry 12 32%
Unspecified 7 19%
Agricultural and Biological Sciences 6 16%
Immunology and Microbiology 6 16%
Nursing and Health Professions 2 5%
Other 4 11%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 August 2016.
All research outputs
#9,622,671
of 12,027,003 outputs
Outputs from Journal of Infectious Diseases
#9,298
of 10,275 outputs
Outputs of similar age
#220,513
of 322,243 outputs
Outputs of similar age from Journal of Infectious Diseases
#90
of 111 outputs
Altmetric has tracked 12,027,003 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 10,275 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.4. This one is in the 5th percentile – i.e., 5% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 322,243 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 18th percentile – i.e., 18% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 111 others from the same source and published within six weeks on either side of this one. This one is in the 9th percentile – i.e., 9% of its contemporaries scored the same or lower than it.