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Integration of Th17- and Lymphotoxin-Derived Signals Initiates Meningeal-Resident Stromal Cell Remodeling to Propagate Neuroinflammation

Overview of attention for article published in Immunity, December 2015
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (97th percentile)
  • High Attention Score compared to outputs of the same age and source (94th percentile)

Citations

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90 Dimensions

Readers on

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147 Mendeley
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Title
Integration of Th17- and Lymphotoxin-Derived Signals Initiates Meningeal-Resident Stromal Cell Remodeling to Propagate Neuroinflammation
Published in
Immunity, December 2015
DOI 10.1016/j.immuni.2015.11.010
Pubmed ID
Authors

Natalia B. Pikor, Jillian L. Astarita, Leslie Summers-Deluca, Georgina Galicia, Joy Qu, Lesley A. Ward, Susan Armstrong, Claudia X. Dominguez, Deepali Malhotra, Brendan Heiden, Robert Kay, Valera Castanov, Hanane Touil, Louis Boon, Paul O’Connor, Amit Bar-Or, Alexandre Prat, Valeria Ramaglia, Samuel Ludwin, Shannon J. Turley, Jennifer L. Gommerman

Abstract

Tertiary lymphoid tissues (TLTs) have been observed in the meninges of multiple sclerosis (MS) patients, but the stromal cells and molecular signals that support TLTs remain unclear. Here, we show that T helper 17 (Th17) cells induced robust TLTs within the brain meninges that were associated with local demyelination during experimental autoimmune encephalitis (EAE). Th17-cell-induced TLTs were underpinned by a network of stromal cells producing extracellular matrix proteins and chemokines, enabling leukocytes to reside within, rather than simply transit through, the meninges. Within the CNS, interactions between lymphotoxin αβ (LTαβ) on Th17 cells and LTβR on meningeal radio-resistant cells were necessary for the propagation of de novo interleukin-17 responses, and activated T cells from MS patients expressed elevated levels of LTβR ligands. Therefore, input from both Th17 cells and the lymphotoxin pathway induce the formation of an immune-competent stromal cell niche in the meninges.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 147 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Japan 1 <1%
Germany 1 <1%
Unknown 145 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 41 28%
Researcher 34 23%
Student > Master 14 10%
Student > Bachelor 11 7%
Student > Doctoral Student 9 6%
Other 24 16%
Unknown 14 10%
Readers by discipline Count As %
Agricultural and Biological Sciences 36 24%
Immunology and Microbiology 35 24%
Medicine and Dentistry 25 17%
Neuroscience 18 12%
Biochemistry, Genetics and Molecular Biology 11 7%
Other 4 3%
Unknown 18 12%

Attention Score in Context

This research output has an Altmetric Attention Score of 80. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 November 2017.
All research outputs
#172,901
of 12,305,682 outputs
Outputs from Immunity
#120
of 3,423 outputs
Outputs of similar age
#6,342
of 302,042 outputs
Outputs of similar age from Immunity
#3
of 50 outputs
Altmetric has tracked 12,305,682 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,423 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 14.3. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 302,042 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 50 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 94% of its contemporaries.