Title |
Embryonic effects of an environmentally relevant PCB mixture in the domestic chicken
|
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Published in |
Environmental Toxicology & Chemistry, August 2018
|
DOI | 10.1002/etc.4218 |
Pubmed ID | |
Authors |
Mary Ann Ottinger, Emma T. Lavoie, Meredith E.B. Bohannon, Allegra M. Marcel, Anna E. Tschiffely, Kara B. Duffy, Moira McKernan, Nichola Thompson, H. Kasen Whitehouse, Kimya Davani, Marci Strauss, Donald E. Tillitt, Josh Lipton, Karen M. Dean |
Abstract |
Studies were conducted to develop methods to assess the effects of a complex mixture of polychlorinated biphenyls (PCBs) in the domestic chicken (Gallus domesticus). Treatments were administered by egg injection to compare embryonic effects of an environmentally relevant PCB congener mixture in the domestic chicken over a range of doses. Chicken eggs were injected with the PCB mixture with a profile similar to that found in avian eggs collected on the upper Hudson River, New York, USA, at doses that spanned 0 to 98 μg/g egg. Eggs were hatched in the laboratory to ascertain hatching success. In the domestic chicken, the median lethal dose was 0.3 μg/g. These data demonstrate adverse effects of an environmentally relevant PCB mixture and provide the basis for further work using in vitro and other models to characterize the potential risk to avian populations. Environ Toxicol Chem 2018;37:2513-2522. © 2018 SETAC. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 11 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Professor | 2 | 18% |
Student > Master | 2 | 18% |
Student > Ph. D. Student | 1 | 9% |
Researcher | 1 | 9% |
Professor > Associate Professor | 1 | 9% |
Other | 0 | 0% |
Unknown | 4 | 36% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 3 | 27% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 9% |
Environmental Science | 1 | 9% |
Medicine and Dentistry | 1 | 9% |
Chemistry | 1 | 9% |
Other | 0 | 0% |
Unknown | 4 | 36% |