Title |
Fractalkine/CX3CL1 protects striatal neurons from synergistic morphine and HIV-1 Tat-induced dendritic losses and death
|
---|---|
Published in |
Molecular Neurodegeneration, November 2011
|
DOI | 10.1186/1750-1326-6-78 |
Pubmed ID | |
Authors |
Masami Suzuki, Nazira El-Hage, Shiping Zou, Yun-Kyung Hahn, Mary E Sorrell, Jamie L Sturgill, Daniel H Conrad, Pamela E Knapp, Kurt F Hauser |
Abstract |
Fractalkine/CX3CL1 and its cognate receptor CX3CR1 are abundantly expressed in the CNS. Fractalkine is an unusual C-X3-C motif chemokine that is important in neuron-microglial communication, a co-receptor for HIV infection, and can be neuroprotective. To assess the effects of fractalkine on opiate-HIV interactive neurotoxicity, wild-type murine striatal neurons were co-cultured with mixed glia from the striata of wild-type or Cx3cr1 knockout mice ± HIV-1 Tat and/or morphine. Time-lapse digital images were continuously recorded at 20 min intervals for up to 72 h using computer-aided microscopy to track the same cells repeatedly. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 3 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 67% |
Science communicators (journalists, bloggers, editors) | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Spain | 1 | 2% |
India | 1 | 2% |
Unknown | 49 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 12 | 24% |
Researcher | 9 | 18% |
Student > Doctoral Student | 5 | 10% |
Professor | 4 | 8% |
Student > Master | 3 | 6% |
Other | 9 | 18% |
Unknown | 9 | 18% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 8 | 16% |
Neuroscience | 6 | 12% |
Biochemistry, Genetics and Molecular Biology | 4 | 8% |
Immunology and Microbiology | 3 | 6% |
Medicine and Dentistry | 3 | 6% |
Other | 14 | 27% |
Unknown | 13 | 25% |