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Fractalkine/CX3CL1 protects striatal neurons from synergistic morphine and HIV-1 Tat-induced dendritic losses and death

Overview of attention for article published in Molecular Neurodegeneration, November 2011
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3 X users

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51 Mendeley
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Title
Fractalkine/CX3CL1 protects striatal neurons from synergistic morphine and HIV-1 Tat-induced dendritic losses and death
Published in
Molecular Neurodegeneration, November 2011
DOI 10.1186/1750-1326-6-78
Pubmed ID
Authors

Masami Suzuki, Nazira El-Hage, Shiping Zou, Yun-Kyung Hahn, Mary E Sorrell, Jamie L Sturgill, Daniel H Conrad, Pamela E Knapp, Kurt F Hauser

Abstract

Fractalkine/CX3CL1 and its cognate receptor CX3CR1 are abundantly expressed in the CNS. Fractalkine is an unusual C-X3-C motif chemokine that is important in neuron-microglial communication, a co-receptor for HIV infection, and can be neuroprotective. To assess the effects of fractalkine on opiate-HIV interactive neurotoxicity, wild-type murine striatal neurons were co-cultured with mixed glia from the striata of wild-type or Cx3cr1 knockout mice ± HIV-1 Tat and/or morphine. Time-lapse digital images were continuously recorded at 20 min intervals for up to 72 h using computer-aided microscopy to track the same cells repeatedly.

X Demographics

X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 51 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 2%
India 1 2%
Unknown 49 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 12 24%
Researcher 9 18%
Student > Doctoral Student 5 10%
Professor 4 8%
Student > Master 3 6%
Other 9 18%
Unknown 9 18%
Readers by discipline Count As %
Agricultural and Biological Sciences 8 16%
Neuroscience 6 12%
Biochemistry, Genetics and Molecular Biology 4 8%
Immunology and Microbiology 3 6%
Medicine and Dentistry 3 6%
Other 14 27%
Unknown 13 25%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 September 2023.
All research outputs
#15,451,440
of 24,495,755 outputs
Outputs from Molecular Neurodegeneration
#753
of 915 outputs
Outputs of similar age
#162,423
of 247,683 outputs
Outputs of similar age from Molecular Neurodegeneration
#14
of 24 outputs
Altmetric has tracked 24,495,755 research outputs across all sources so far. This one is in the 34th percentile – i.e., 34% of other outputs scored the same or lower than it.
So far Altmetric has tracked 915 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.7. This one is in the 15th percentile – i.e., 15% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 247,683 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 32nd percentile – i.e., 32% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 24 others from the same source and published within six weeks on either side of this one. This one is in the 45th percentile – i.e., 45% of its contemporaries scored the same or lower than it.