↓ Skip to main content

Determinants of venom-specific IgE antibody concentration during long-term wasp venom immunotherapy

Overview of attention for article published in Clinical and Molecular Allergy, December 2015
Altmetric Badge

Mentioned by

facebook
1 Facebook page

Citations

dimensions_citation
3 Dimensions

Readers on

mendeley
19 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Determinants of venom-specific IgE antibody concentration during long-term wasp venom immunotherapy
Published in
Clinical and Molecular Allergy, December 2015
DOI 10.1186/s12948-015-0036-6
Pubmed ID
Authors

Valerio Pravettoni, Valerio Pravettoni, Marta Piantanida, Laura Primavesi, Stella Forti, Elide A. Pastorello

Abstract

Venom immunotherapy (VIT) is an effective treatment for subjects with systemic allergic reactions (SR) to Hymenoptera stings, however there are few studies concerning the relevance of the venom specific IgE changes to decide about VIT cessation. We assessed IgE changes during a 5-year VIT, in patients stung and protected within the first 3 years (SP 0-3) or in the last 2 years (SP 3-5), and in patients not stung (NoS), to evaluate possible correlations between IgE changes and clinical protection. Yellow jacket venom (YJV)-allergic patients who completed 5 years of VIT were retrospectively evaluated. Baseline IgE levels and after the 3rd and the 5th year of VIT were determined; all patients were asked about field stings and SRs. A total of 232 YJV-allergic patients were included and divided into the following groups: 84 NoS, 72 SP 0-3 and 76 SP 3-5. IgE levels decreased during VIT compared to baseline values (χ(2) = 346.029, p < 0.001). Recent vespid stings accounted for significantly higher IgE levels despite clinical protection. IgE levels after 5 years of VIT correlated significantly with Mueller grade (F = 2.778, p = 0.012) and age (F = 6.672, p = 0.002). During follow-up from 1 to 10 years after VIT discontinuation, 35.2 % of the contacted patients reported at least one field sting without SR. The yellow jacket-VIT temporal stopping criterion of 5 years duration did not result in undetectable IgE levels, despite a long-lasting protection. A mean IgE decrease from 58 to 70 % was observed, and it was less marked in elderly patients or in subjects with higher Mueller grade SR.

Mendeley readers

The data shown below were compiled from readership statistics for 19 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 19 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 6 32%
Student > Master 2 11%
Researcher 2 11%
Student > Doctoral Student 2 11%
Student > Bachelor 1 5%
Other 6 32%
Readers by discipline Count As %
Medicine and Dentistry 5 26%
Agricultural and Biological Sciences 5 26%
Immunology and Microbiology 2 11%
Computer Science 1 5%
Biochemistry, Genetics and Molecular Biology 1 5%
Other 4 21%
Unknown 1 5%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 December 2015.
All research outputs
#5,804,978
of 6,787,729 outputs
Outputs from Clinical and Molecular Allergy
#66
of 81 outputs
Outputs of similar age
#237,314
of 293,077 outputs
Outputs of similar age from Clinical and Molecular Allergy
#5
of 7 outputs
Altmetric has tracked 6,787,729 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 81 research outputs from this source. They receive a mean Attention Score of 3.4. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 293,077 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 7 others from the same source and published within six weeks on either side of this one. This one has scored higher than 2 of them.