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Coordination and redox interactions of β-lactam antibiotics with Cu2+ in physiological settings and the impact on antibacterial activity

Overview of attention for article published in Free Radical Biology & Medicine, December 2018
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Title
Coordination and redox interactions of β-lactam antibiotics with Cu2+ in physiological settings and the impact on antibacterial activity
Published in
Free Radical Biology & Medicine, December 2018
DOI 10.1016/j.freeradbiomed.2018.09.038
Pubmed ID
Authors

Bojana Božić, Jelena Korać, Dalibor M. Stanković, Marina Stanić, Mima Romanović, Jelena Bogdanović Pristov, Snežana Spasić, Ana Popović-Bijelić, Ivan Spasojević, Milica Bajčetić

Abstract

An increase in the copper pool in body fluids has been related to a number of pathological conditions, including infections. Copper ions may affect antibiotics via the formation of coordination bonds and/or redox reactions. Herein, we analyzed the interactions of Cu2+ with eight β-lactam antibiotics using UV-Vis spectrophotometry, EPR spectroscopy, and electrochemical methods. Penicillin G did not show any detectable interactions with Cu2+. Ampicillin, amoxicillin and cephalexin formed stable colored complexes with octahedral coordination environment of Cu2+ with tetragonal distortion, and primary amine group as the site of coordinate bond formation. These β-lactams increased the solubility of Cu2+ in the phosphate buffer. Ceftazidime and Cu2+ formed a complex with a similar geometry and gave rise to an organic radical. Ceftriaxone-Cu2+ complex appears to exhibit different geometry. All complexes showed 1:1 stoichiometry. Cefaclor reduced Cu2+ to Cu1+ that further reacted with molecular oxygen to produce hydrogen peroxide. Finally, meropenem underwent degradation in the presence of copper. The analysis of activity against Escherichia coli and Staphylococcus aureus showed that the effects of meropenem, amoxicillin, ampicillin, and ceftriaxone were significantly hindered in the presence of copper ions. The interactions with copper ions should be taken into account regarding the problem of antibiotic resistance and in the selection of the most efficient antimicrobial therapy for patients with altered copper homeostasis.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 17 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 17 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 5 29%
Student > Master 3 18%
Student > Bachelor 3 18%
Student > Ph. D. Student 2 12%
Lecturer > Senior Lecturer 1 6%
Other 2 12%
Unknown 1 6%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 4 24%
Pharmacology, Toxicology and Pharmaceutical Science 2 12%
Chemistry 2 12%
Medicine and Dentistry 2 12%
Agricultural and Biological Sciences 1 6%
Other 2 12%
Unknown 4 24%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 October 2019.
All research outputs
#12,682,898
of 15,971,647 outputs
Outputs from Free Radical Biology & Medicine
#3,179
of 4,014 outputs
Outputs of similar age
#207,301
of 277,428 outputs
Outputs of similar age from Free Radical Biology & Medicine
#41
of 62 outputs
Altmetric has tracked 15,971,647 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,014 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.5. This one is in the 12th percentile – i.e., 12% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 277,428 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 14th percentile – i.e., 14% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 62 others from the same source and published within six weeks on either side of this one. This one is in the 16th percentile – i.e., 16% of its contemporaries scored the same or lower than it.