Ionizing radiation directly affects DNA structure by inducing DNA breaks, particularly, DSBs. https://t.co/nQ6wnX4Gvq
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@michaelcurzi yes, radiation damages. can be repaired/dealt with, doesn't progress. but some may have deficiencies w their DNA repair mechanisms, eg https://t.co/wSmc8x64EW there's also the difference between damage to the mitochondrial dna and to the nuc
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RT @keisuke4713: 乳ガン患者 電離放射線誘発DNA損傷https://t.co/eqLim7Gpkm 放射線照射後に活性化するDNA修復機構欠損 →DNA損傷、特にDNA二本鎖切断(DSB) DSBは希だが、最も致死的機序、多くの場合電離放射線で起きる BRCA…
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乳ガン患者 電離放射線誘発DNA損傷https://t.co/eqLim7Gpkm 放射線照射後に活性化するDNA修復機構欠損 →DNA損傷、特にDNA二本鎖切断(DSB) DSBは希だが、最も致死的機序、多くの場合電離放射線で起きる BRCA-1・BRCA-2蛋白はDSB損傷修復に関与、🧬幾つか変異→乳房・他新形成発症risk⬆️ DSB修復経路 https://t.co/j6IeJMUOii