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Selection of recombinant MVA by rescue of the essential D4R gene

Overview of attention for article published in Virology Journal, January 2011
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Title
Selection of recombinant MVA by rescue of the essential D4R gene
Published in
Virology Journal, January 2011
DOI 10.1186/1743-422x-8-529
Pubmed ID
Authors

Patricia S Ricci, Birgit Schäfer, Thomas R Kreil, Falko G Falkner, Georg W Holzer

Abstract

Modified vaccinia virus Ankara (MVA) has become a promising vaccine vector due to its immunogenicity and its proven safety in humans. As a general approach for stringent and rapid selection of recombinant MVA, we assessed marker rescue of the essential viral D4R gene in an engineered deletion mutant that is fully replication defective in wild-type cells. Recombinant, replicating virus was obtained by re-introduction of the deleted viral gene as a dominant selection marker into the deletion mutant.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 10 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 10%
Unknown 9 90%

Demographic breakdown

Readers by professional status Count As %
Student > Master 3 30%
Student > Bachelor 2 20%
Researcher 2 20%
Student > Ph. D. Student 2 20%
Professor > Associate Professor 1 10%
Other 0 0%
Readers by discipline Count As %
Agricultural and Biological Sciences 6 60%
Biochemistry, Genetics and Molecular Biology 2 20%
Computer Science 1 10%
Immunology and Microbiology 1 10%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 December 2011.
All research outputs
#11,130,758
of 12,515,237 outputs
Outputs from Virology Journal
#1,928
of 2,099 outputs
Outputs of similar age
#183,946
of 214,524 outputs
Outputs of similar age from Virology Journal
#140
of 207 outputs
Altmetric has tracked 12,515,237 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,099 research outputs from this source. They receive a mean Attention Score of 3.5. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 214,524 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 207 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.