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Suppression of Proinflammatory and Prosurvival Biomarkers in Oral Cancer Patients Consuming a Black Raspberry Phytochemical-Rich Troche

Overview of attention for article published in Cancer Prevention Research, February 2016
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (88th percentile)
  • High Attention Score compared to outputs of the same age and source (80th percentile)

Mentioned by

news
1 news outlet
twitter
2 tweeters
facebook
3 Facebook pages
reddit
1 Redditor
video
1 video uploader

Citations

dimensions_citation
41 Dimensions

Readers on

mendeley
66 Mendeley
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Title
Suppression of Proinflammatory and Prosurvival Biomarkers in Oral Cancer Patients Consuming a Black Raspberry Phytochemical-Rich Troche
Published in
Cancer Prevention Research, February 2016
DOI 10.1158/1940-6207.capr-15-0187
Pubmed ID
Authors

Thomas J. Knobloch, Lana K. Uhrig, Dennis K. Pearl, Bruce C. Casto, Blake M. Warner, Steven K. Clinton, Christine L. Sardo-Molmenti, Jeanette M. Ferguson, Brett T. Daly, Kenneth Riedl, Steven J. Schwartz, Yael Vodovotz, Anthony J. Buchta, David E. Schuller, Enver Ozer, Amit Agrawal, Christopher M. Weghorst

Abstract

Black raspberries (BRBs) demonstrate potent inhibition of aerodigestive tract carcinogenesis in animal models. However, translational clinical trials evaluating the ability of BRB phytochemicals to impact molecular biomarkers in the oral mucosa remain limited. The present phase 0 study addresses a fundamental question for oral cancer food-based prevention: Do BRB phytochemicals successfully reach the targeted oral tissues and reduce pro-inflammatory and anti-apoptotic gene expression profiles? Patients with biopsy-confirmed oral squamous cell carcinomas (OSCCs) administered oral troches containing freeze-dried BRB powder from the time of enrollment to the date of curative intent surgery (13.9±1.27 days). Transcriptional biomarkers were evaluated in patient-matched OSCCs and non-involved high at-risk mucosa (HARM) for BRB-associated changes. Significant expression differences between baseline OSCC and HARM tissues were confirmed using a panel of genes commonly deregulated during oral carcinogenesis. Following BRB troche administration, the expression of pro-survival genes (AURKA, BIRC5, EGFR) and pro-inflammatory genes (NFKB1, PTGS2) were significantly reduced. There were no BRB-associated Grade 3-4 toxicities or adverse events and 79.2% (N=30) of patients successfully completed the study with high levels of compliance (97.2%). The BRB phytochemicals cyanidin-3-rutinoside and cyanidin-3-xylosylrutinoside were detected in all OSCC tissues analyzed, demonstrating that bioactive components were successfully reaching targeted OSCC tissues. We confirmed that hallmark anti-apoptotic and pro-inflammatory molecular biomarkers were over-expressed in OSCCs and that their gene expression was significantly reduced following BRB troche administration. Since these molecular biomarkers are fundamental to oral carcinogenesis and are modifiable, they may represent emerging biomarkers of molecular efficacy for BRB-mediated oral cancer chemoprevention.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 66 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 2%
Brazil 1 2%
Unknown 64 97%

Demographic breakdown

Readers by professional status Count As %
Student > Master 13 20%
Researcher 8 12%
Student > Postgraduate 6 9%
Student > Bachelor 5 8%
Other 5 8%
Other 13 20%
Unknown 16 24%
Readers by discipline Count As %
Medicine and Dentistry 19 29%
Agricultural and Biological Sciences 11 17%
Biochemistry, Genetics and Molecular Biology 6 9%
Pharmacology, Toxicology and Pharmaceutical Science 5 8%
Psychology 1 2%
Other 4 6%
Unknown 20 30%

Attention Score in Context

This research output has an Altmetric Attention Score of 13. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 May 2022.
All research outputs
#2,143,517
of 21,322,016 outputs
Outputs from Cancer Prevention Research
#227
of 1,303 outputs
Outputs of similar age
#44,394
of 402,272 outputs
Outputs of similar age from Cancer Prevention Research
#5
of 25 outputs
Altmetric has tracked 21,322,016 research outputs across all sources so far. Compared to these this one has done well and is in the 89th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,303 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.1. This one has done well, scoring higher than 82% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 402,272 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 88% of its contemporaries.
We're also able to compare this research output to 25 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 80% of its contemporaries.