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Clinical-epidemiological and laboratory profiles of severe Schistosomiasis mansoni infections at a university hospital

Overview of attention for article published in Clinics, November 2018
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Clinical-epidemiological and laboratory profiles of severe Schistosomiasis mansoni infections at a university hospital
Published in
Clinics, November 2018
DOI 10.6061/clinics/2017/e340
Pubmed ID

MC Espírito-Santo, MR Magalhães, N Mortari, FO França, EJ Luna, RC Gryschek


Schistosomiasis remains a public health problem. This was a descriptive and retrospective study of 42 patients with a severe form of schistosomiasis who were admitted to the outpatient clinic of the Faculdade de Medicina da Universidade de São Paulo, São Paulo, in São Paulo, Brazil. A data collection questionnaire was designed from the patient charts, and the following variables were evaluated: age, sex, place of birth, occupation, signs and symptoms of schistosomiasis, data from laboratory and imaging examinations, data regarding treatment outcomes, and the existence of comorbidities. Statistical analysis was carried out using Statistical Package for the Social Sciences 15.0 and Microsoft Excel 2003 software. The significance levels of the tests were fixed, accepting 5% type 1 error (α=0.05). Since this was a retrospective observational study, not all data were available for analysis. The mean age of the patients was 48.24 years; 57.1% were male. Statistically significant associations were observed between splenomegaly and thrombocytopenia (p=0.004) and between splenomegaly and leukopenia (p=0.046); however, only 4.5% of the patients had esophageal hemorrhage. Some patients received a specific treatment; of those, 42% took praziquantel, and 35.4% took oxamniquine. Nonspecific drug therapy was given as follows: 65% received propranolol, 90% omeprazole, and 43.6% aluminum hydroxide. The other treatments were as follows: 92.9% of patients underwent endoscopic treatment, 85% received sclerotherapy, and 62.5% used elastic bandages. This preliminary study presents a multidisciplinary outpatient follow-up associated with endoscopic and drug treatments that may be effective at preventing bleeding.

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Geographical breakdown

Country Count As %
Unknown 21 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 5 24%
Researcher 2 10%
Student > Ph. D. Student 2 10%
Student > Master 2 10%
Other 1 5%
Other 2 10%
Unknown 7 33%
Readers by discipline Count As %
Medicine and Dentistry 6 29%
Nursing and Health Professions 2 10%
Agricultural and Biological Sciences 2 10%
Pharmacology, Toxicology and Pharmaceutical Science 1 5%
Computer Science 1 5%
Other 1 5%
Unknown 8 38%