Title |
Judging quality of current septic shock definitions and criteria
|
---|---|
Published in |
Critical Care, December 2015
|
DOI | 10.1186/s13054-015-1164-6 |
Pubmed ID | |
Authors |
Manu Shankar-Hari, Guido Bertolini, Frank M. Brunkhorst, Rinaldo Bellomo, Djillali Annane, Clifford S. Deutschman, Mervyn Singer |
Abstract |
Septic shock definitions are being revisited. We assess the feasibility, reliability, and validity characteristics of the current definitions and criteria of septic shock. Septic shock is conceptualised as cardiovascular dysfunction, tissue perfusion and cellular abnormalities caused by infection. Currently, for feasibility, septic shock is identified at the bedside by using either hypotension or a proxy for tissue perfusion/cellular abnormalities (e.g., hyperlactatemia). We propose that concurrent presence of cardiovascular dysfunction and perfusion/cellular abnormalities could improve validity of septic shock diagnosis, as we are more likely to identify a patient population with all elements of the illness concept. This epidemiological refinement should not affect clinical care and may aid study design to identify illness-specific biomarkers and interventions. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 16 | 23% |
United Kingdom | 8 | 11% |
Australia | 5 | 7% |
Spain | 3 | 4% |
Italy | 2 | 3% |
Greece | 1 | 1% |
South Africa | 1 | 1% |
Saudi Arabia | 1 | 1% |
Netherlands | 1 | 1% |
Other | 10 | 14% |
Unknown | 22 | 31% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 41 | 59% |
Scientists | 14 | 20% |
Practitioners (doctors, other healthcare professionals) | 13 | 19% |
Science communicators (journalists, bloggers, editors) | 2 | 3% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 1% |
Russia | 1 | 1% |
Unknown | 78 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Other | 16 | 20% |
Researcher | 10 | 13% |
Student > Postgraduate | 7 | 9% |
Student > Ph. D. Student | 6 | 8% |
Professor | 6 | 8% |
Other | 21 | 26% |
Unknown | 14 | 18% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 47 | 59% |
Biochemistry, Genetics and Molecular Biology | 3 | 4% |
Nursing and Health Professions | 3 | 4% |
Agricultural and Biological Sciences | 2 | 3% |
Immunology and Microbiology | 2 | 3% |
Other | 6 | 8% |
Unknown | 17 | 21% |