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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Fyn is a redox sensor involved in solar ultraviolet light-induced signal transduction in skin carcinogenesis
|
|---|---|
| Published in |
Oncogene, December 2015
|
| DOI | 10.1038/onc.2015.471 |
| Pubmed ID | |
| Authors |
J-E Kim, E Roh, M H Lee, D H Yu, D J Kim, T-G Lim, S K Jung, C Peng, Y-Y Cho, S Dickinson, D Alberts, G T Bowden, J Einspahr, S P Stratton, C Curiel-Lewandrowski, A M Bode, K W Lee, Z Dong |
| Abstract |
Solar ultraviolet (UV) light is a major etiological factor in skin carcinogenesis, with solar UV-stimulated signal transduction inducing pathological changes and skin damage. The primary sensor of solar UV-induced cellular signaling has not been identified. We use an experimental system of solar simulated light (SSL) to mimic solar UV and we demonstrate that Fyn is a primary redox sensor involved in SSL-induced signal transduction. Reactive oxygen species (ROS) generated by SSL exposure directly oxidize Cys488 of Fyn, resulting in increased Fyn kinase activity. Fyn oxidation was increased in mouse skin after SSL exposure and Fyn-knockout mice formed larger and more tumors compared with Fyn wild-type mice when exposed to SSL for an extended period of time. Murine embryonic fibroblasts (MEFs) lacking Fyn and cells in which Fyn expression was knocked down were resistant to SSL-induced apoptosis. Furthermore, cells expressing mutant Fyn (C448A) were resistant to SSL-induced apoptosis. These findings suggest that Fyn acts as a regulatory nexus between solar UV, ROS and signal transduction during skin carcinogenesis.Oncogene advance online publication, 21 December 2015; doi:10.1038/onc.2015.471. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Science communicators (journalists, bloggers, editors) | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 17 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 17 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 7 | 41% |
| Student > Master | 2 | 12% |
| Student > Ph. D. Student | 1 | 6% |
| Professor | 1 | 6% |
| Student > Postgraduate | 1 | 6% |
| Other | 0 | 0% |
| Unknown | 5 | 29% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 5 | 29% |
| Biochemistry, Genetics and Molecular Biology | 2 | 12% |
| Unspecified | 1 | 6% |
| Medicine and Dentistry | 1 | 6% |
| Neuroscience | 1 | 6% |
| Other | 1 | 6% |
| Unknown | 6 | 35% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 January 2016.
All research outputs
#19,627,490
of 24,140,950 outputs
Outputs from Oncogene
#9,912
of 10,864 outputs
Outputs of similar age
#290,759
of 397,905 outputs
Outputs of similar age from Oncogene
#69
of 88 outputs
Altmetric has tracked 24,140,950 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 10,864 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.3. This one is in the 4th percentile – i.e., 4% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 397,905 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 14th percentile – i.e., 14% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 88 others from the same source and published within six weeks on either side of this one. This one is in the 12th percentile – i.e., 12% of its contemporaries scored the same or lower than it.