↓ Skip to main content

Rare double-hit with two translocations involving IGH both, with BCL2 and BCL3, in a monoclonal B-cell lymphoma/leukemia.

Overview of attention for article published in Molecular Cytogenetics, January 2015
Altmetric Badge

About this Attention Score

  • Average Attention Score compared to outputs of the same age
  • Average Attention Score compared to outputs of the same age and source

Mentioned by

twitter
2 tweeters

Citations

dimensions_citation
4 Dimensions

Readers on

mendeley
10 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Rare double-hit with two translocations involving IGH both, with BCL2 and BCL3, in a monoclonal B-cell lymphoma/leukemia.
Published in
Molecular Cytogenetics, January 2015
DOI 10.1186/s13039-015-0203-y
Pubmed ID
Authors

Alpatov, Roman, Carstens, Billie, Harding, Kimberly, Jarrett, Carolyn, Balakhani, Sudabeh, Lincoln, Jessica, Brzeskiewicz, Peter, Guo, Yu, Ohene-Mobley, Alex, LeRoux, Jamie, McDaniel, Veronica, Meltesen, Lynne, Minka, Diane, Patel, Mahendra, Manavi, Cyrus, Swisshelm, Karen, Roman Alpatov, Billie Carstens, Kimberly Harding, Carolyn Jarrett, Sudabeh Balakhani, Jessica Lincoln, Peter Brzeskiewicz, Yu Guo, Alex Ohene-Mobley, Jamie LeRoux, Veronica McDaniel, Lynne Meltesen, Diane Minka, Mahendra Patel, Cyrus Manavi, Karen Swisshelm

Abstract

Chronic Lymphocytic Leukemia (CLL) is a lymphoproliferative disease characterized by multiple recurring clonal cytogenetic anomalies and is the most common leukemia in adults. Chromosomal abnormalities associated with CLL include trisomy 12 and IGH;BCL3 rearrangement [t(14;19)(q32;q13)] that juxtaposes a proto-oncogenic gene BCL3 and an immunoglobulin heavy chain, a translocation that may be associated with shorter survival. In addition to the IGH;BCL3 rearrangement, other translocations involving 14q32 locus are involved in various lymphoproliferative pathologies pointing toward the significance of IGH locus in oncogenic progression. Significantly, in the majority of B-cell neoplasms that carry an IGH;BCL3 rearrangement, it is a sole translocation involving an IGH locus. We report a patient who, in addition to trisomy 12, carried a rare double-hit translocation characterized by the IGH;BCL3 translocation and an additional clonal IGH;BCL2 translocation involving IGH and another proto-oncogene BCL2, t(14;18)(q32;q21), commonly found in follicular lymphoma. Further single nucleotide polymorphism (SNP) array-based analysis detected a duplication of the 58.8 kb region at 19q13.32 adjacent to the BCL3 translocation junction on chromosome 19q13. Interestingly, the duplicated region contained ERCC2 gene, which encodes a DNA excision repair protein involved in the cancer-prone syndrome, xeroderma pigmentosum. Taken together our findings indicate the existence of double-translocation driven oncogenic events involving both IGH loci and proto-oncogenes BCL2 and BCL3. Importantly, the IGH;BCL3 translocation was characterized by the duplication of the genomic region adjacent to BCL3, containing a major DNA repair factor, ERCC2.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 10 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 10 100%

Demographic breakdown

Readers by professional status Count As %
Unspecified 2 20%
Researcher 2 20%
Professor 1 10%
Student > Bachelor 1 10%
Student > Ph. D. Student 1 10%
Other 3 30%
Readers by discipline Count As %
Medicine and Dentistry 5 50%
Biochemistry, Genetics and Molecular Biology 2 20%
Unspecified 2 20%
Agricultural and Biological Sciences 1 10%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 March 2016.
All research outputs
#5,304,525
of 7,356,005 outputs
Outputs from Molecular Cytogenetics
#129
of 219 outputs
Outputs of similar age
#193,964
of 306,851 outputs
Outputs of similar age from Molecular Cytogenetics
#18
of 36 outputs
Altmetric has tracked 7,356,005 research outputs across all sources so far. This one is in the 24th percentile – i.e., 24% of other outputs scored the same or lower than it.
So far Altmetric has tracked 219 research outputs from this source. They receive a mean Attention Score of 1.8. This one is in the 34th percentile – i.e., 34% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 306,851 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 30th percentile – i.e., 30% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 36 others from the same source and published within six weeks on either side of this one. This one is in the 30th percentile – i.e., 30% of its contemporaries scored the same or lower than it.