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Antioxidant, analgesic and anti-inflammatory effects of lavender essential oil

Overview of attention for article published in Anais da Academia Brasileira de Ciências, August 2015
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Title
Antioxidant, analgesic and anti-inflammatory effects of lavender essential oil
Published in
Anais da Academia Brasileira de Ciências, August 2015
DOI 10.1590/0001-3765201520150056
Pubmed ID
Authors

GABRIELA L. DA SILVA, CAROLINA LUFT, ADROALDO LUNARDELLI, ROBSON H. AMARAL, DENIZAR A. DA SILVA MELO, MÁRCIO V.F. DONADIO, FERNANDA B. NUNES, MARCOS S. DE AZAMBUJA, JOÃO C. SANTANA, CRISTINA M.B. MORAES, RICARDO O. MELLO, EDUARDO CASSEL, MARCOS AURÉLIO DE ALMEIDA PEREIRA, JARBAS R. DE OLIVEIRA

Abstract

Several studies have investigated the antinociceptive, immunomodulatory and anti-inflammatory properties of compounds found in the lavender essential oil (LEO), however to date, there is still lack of substantial data. The objective of this study was to assess the antioxidant, anti-inflammatory and antinociceptive effects of lavender essential oil. The 1,1-diphenyl-2-picrylhydrazyl radical decolorization assay was used for antioxidant activity evaluation. The anti-inflammatory activity was tested using two models of acute inflammation: carrageenan-induced pleurisy and croton oil-induced ear edema. The antinociceptive activity was tested using the pain model induced by formalin. LEO has antioxidant activity, which is dose-dependent response. The inflammatory response evoked by carrageenan and by croton oil was reduced through the pre-treatment of animals with LEO. In the pleurisy model, the drug used as positive control, dexamethasone, was more efficacious. However, in the ear swelling, the antiedematogenic effect of the oil was similar to that observed for dexamethasone. In the formalin test, LEO consistently inhibited spontaneous nociception and presented a similar effect to that of tramadol. The results of this study reveal (in vivo) the analgesic and anti-inflammatory activities of LEO and demonstrates its important therapeutic potential.

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Mendeley readers

The data shown below were compiled from readership statistics for 201 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 201 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 44 22%
Student > Master 29 14%
Researcher 18 9%
Student > Ph. D. Student 16 8%
Student > Postgraduate 10 5%
Other 33 16%
Unknown 51 25%
Readers by discipline Count As %
Agricultural and Biological Sciences 25 12%
Medicine and Dentistry 24 12%
Biochemistry, Genetics and Molecular Biology 20 10%
Pharmacology, Toxicology and Pharmaceutical Science 18 9%
Chemistry 15 7%
Other 41 20%
Unknown 58 29%