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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Increased copy number for methylated maternal 15q duplications leads to changes in gene and protein expression in human cortical samples
|
|---|---|
| Published in |
Molecular Autism, December 2011
|
| DOI | 10.1186/2040-2392-2-19 |
| Pubmed ID | |
| Authors |
Haley A Scoles, Nora Urraca, Samuel W Chadwick, Lawrence T Reiter, Janine M LaSalle |
| Abstract |
Duplication of chromosome 15q11-q13 (dup15q) accounts for approximately 3% of autism cases. Chromosome 15q11-q13 contains imprinted genes necessary for normal mammalian neurodevelopment controlled by a differentially methylated imprinting center (imprinting center of the Prader-Willi locus, PWS-IC). Maternal dup15q occurs as both interstitial duplications and isodicentric chromosome 15. Overexpression of the maternally expressed gene UBE3A is predicted to be the primary cause of the autistic features associated with dup15q. Previous analysis of two postmortem dup15q frontal cortical samples showed heterogeneity between the two cases, with one showing levels of the GABAA receptor genes, UBE3A and SNRPN in a manner not predicted by copy number or parental imprint. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Australia | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 81 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | 5% |
| Netherlands | 1 | 1% |
| Unknown | 76 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 22 | 27% |
| Researcher | 15 | 19% |
| Student > Master | 13 | 16% |
| Student > Bachelor | 7 | 9% |
| Professor | 5 | 6% |
| Other | 9 | 11% |
| Unknown | 10 | 12% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 19 | 23% |
| Biochemistry, Genetics and Molecular Biology | 18 | 22% |
| Neuroscience | 12 | 15% |
| Medicine and Dentistry | 10 | 12% |
| Psychology | 3 | 4% |
| Other | 6 | 7% |
| Unknown | 13 | 16% |
Attention Score in Context
This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 February 2023.
All research outputs
#6,397,101
of 23,592,647 outputs
Outputs from Molecular Autism
#443
of 686 outputs
Outputs of similar age
#55,915
of 246,103 outputs
Outputs of similar age from Molecular Autism
#8
of 9 outputs
Altmetric has tracked 23,592,647 research outputs across all sources so far. This one has received more attention than most of these and is in the 72nd percentile.
So far Altmetric has tracked 686 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 28.4. This one is in the 35th percentile – i.e., 35% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 246,103 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 76% of its contemporaries.
We're also able to compare this research output to 9 others from the same source and published within six weeks on either side of this one.