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Increased copy number for methylated maternal 15q duplications leads to changes in gene and protein expression in human cortical samples.

Overview of attention for article published in Molecular Autism, December 2011
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (61st percentile)

Mentioned by

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1 tweeter
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1 Google+ user

Citations

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49 Dimensions

Readers on

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52 Mendeley
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Title
Increased copy number for methylated maternal 15q duplications leads to changes in gene and protein expression in human cortical samples.
Published in
Molecular Autism, December 2011
DOI 10.1186/2040-2392-2-19
Pubmed ID
Authors

Scoles HA, Urraca N, Chadwick SW, Reiter LT, Lasalle JM, Haley A Scoles, Nora Urraca, Samuel W Chadwick, Lawrence T Reiter, Janine M LaSalle

Abstract

Duplication of chromosome 15q11-q13 (dup15q) accounts for approximately 3% of autism cases. Chromosome 15q11-q13 contains imprinted genes necessary for normal mammalian neurodevelopment controlled by a differentially methylated imprinting center (imprinting center of the Prader-Willi locus, PWS-IC). Maternal dup15q occurs as both interstitial duplications and isodicentric chromosome 15. Overexpression of the maternally expressed gene UBE3A is predicted to be the primary cause of the autistic features associated with dup15q. Previous analysis of two postmortem dup15q frontal cortical samples showed heterogeneity between the two cases, with one showing levels of the GABAA receptor genes, UBE3A and SNRPN in a manner not predicted by copy number or parental imprint.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 52 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 4 8%
Netherlands 1 2%
Unknown 47 90%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 15 29%
Researcher 12 23%
Student > Master 8 15%
Student > Bachelor 5 10%
Professor 3 6%
Other 9 17%
Readers by discipline Count As %
Agricultural and Biological Sciences 16 31%
Biochemistry, Genetics and Molecular Biology 12 23%
Medicine and Dentistry 9 17%
Neuroscience 7 13%
Unspecified 5 10%
Other 3 6%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 March 2013.
All research outputs
#2,162,751
of 4,680,920 outputs
Outputs from Molecular Autism
#188
of 218 outputs
Outputs of similar age
#81,561
of 233,451 outputs
Outputs of similar age from Molecular Autism
#2
of 2 outputs
Altmetric has tracked 4,680,920 research outputs across all sources so far. This one has received more attention than most of these and is in the 51st percentile.
So far Altmetric has tracked 218 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.9. This one is in the 11th percentile – i.e., 11% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 233,451 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 61% of its contemporaries.
We're also able to compare this research output to 2 others from the same source and published within six weeks on either side of this one.