Title |
R-flurbiprofen, a novel nonsteroidal anti-inflammatory drug, decreases cell proliferation and induces apoptosis in pituitary adenoma cells in vitro
|
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Published in |
Journal of Neuro-Oncology, September 2011
|
DOI | 10.1007/s11060-011-0712-4 |
Pubmed ID | |
Authors |
James K. Liu, Smruti K. Patel, David L. Gillespie, Kum Whang, William T. Couldwell |
Abstract |
R-flurbiprofen, a nonsteroidal anti-inflammatory drug derivative, has been shown to inhibit colonic adenoma formation in mice. We investigated the effects of R-flurbiprofen on cell proliferation and apoptosis in pituitary adenoma cell lines. GH4C1 rat pituitary cell line cultures and low-passage human primary pituitary cell cultures were treated with varying concentrations of R-flurbiprofen (0.1-1.0 mM). R-flurbiprofen inhibited cell proliferation in a dose-dependent fashion. A terminal deoxynucleotidyl transferase dUTP nick end labeling assay and chromatin condensation/dead cell apoptosis assay demonstrated induction of apoptosis at higher concentrations of R-flurbiprofen. R-flurbiprofen decreases cell proliferation and induces apoptosis in pituitary adenoma cells in vitro. This may be a potential therapy in the management of pituitary adenoma. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 15 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 4 | 27% |
Student > Ph. D. Student | 4 | 27% |
Student > Master | 2 | 13% |
Student > Doctoral Student | 1 | 7% |
Researcher | 1 | 7% |
Other | 1 | 7% |
Unknown | 2 | 13% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 4 | 27% |
Chemistry | 2 | 13% |
Agricultural and Biological Sciences | 2 | 13% |
Biochemistry, Genetics and Molecular Biology | 1 | 7% |
Neuroscience | 1 | 7% |
Other | 1 | 7% |
Unknown | 4 | 27% |