Title |
Integrative analysis of RUNX1 downstream pathways and target genes
|
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Published in |
BMC Genomics, July 2008
|
DOI | 10.1186/1471-2164-9-363 |
Pubmed ID | |
Authors |
Joëlle Michaud, Ken M Simpson, Robert Escher, Karine Buchet-Poyau, Tim Beissbarth, Catherine Carmichael, Matthew E Ritchie, Frédéric Schütz, Ping Cannon, Marjorie Liu, Xiaofeng Shen, Yoshiaki Ito, Wendy H Raskind, Marshall S Horwitz, Motomi Osato, David R Turner, Terence P Speed, Maria Kavallaris, Gordon K Smyth, Hamish S Scott |
Abstract |
The RUNX1 transcription factor gene is frequently mutated in sporadic myeloid and lymphoid leukemia through translocation, point mutation or amplification. It is also responsible for a familial platelet disorder with predisposition to acute myeloid leukemia (FPD-AML). The disruption of the largely unknown biological pathways controlled by RUNX1 is likely to be responsible for the development of leukemia. We have used multiple microarray platforms and bioinformatic techniques to help identify these biological pathways to aid in the understanding of why RUNX1 mutations lead to leukemia. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 4 | 3% |
United Kingdom | 3 | 2% |
France | 1 | <1% |
Australia | 1 | <1% |
Netherlands | 1 | <1% |
Portugal | 1 | <1% |
Israel | 1 | <1% |
Denmark | 1 | <1% |
Mexico | 1 | <1% |
Other | 0 | 0% |
Unknown | 143 | 91% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 49 | 31% |
Researcher | 37 | 24% |
Student > Bachelor | 12 | 8% |
Student > Master | 9 | 6% |
Professor | 7 | 4% |
Other | 26 | 17% |
Unknown | 17 | 11% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 58 | 37% |
Biochemistry, Genetics and Molecular Biology | 32 | 20% |
Medicine and Dentistry | 21 | 13% |
Computer Science | 7 | 4% |
Mathematics | 4 | 3% |
Other | 15 | 10% |
Unknown | 20 | 13% |